Time to positivity of blood culture and its prognostic value in bloodstream infection

The purpose of this study was to investigate the relationship between the time to positivity (TTP) of blood cultures and outcome in patients with bloodstream infections (BSIs). Between January 1st, 2011 and December 31st, 2013, the blood cultures of inpatients with BSI or catheter-related BSI were c...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2016-04, Vol.35 (4), p.619-624
Main Authors: Ning, Y., Hu, R., Yao, G., Bo, S.
Format: Article
Language:English
Subjects:
Accuracy
Adolescent
Adult
Aerobiosis
Aged
Aged, 80 and over
Anaerobiosis
Biomedical and Life Sciences
Biomedicine
Blood
Blood - microbiology
Catheters
China
E coli
Female
Hospitals
Hospitals, University
Humans
Internal Medicine
Laboratories
Male
Medical instruments
Medical Microbiology
Microbiological Techniques - methods
Middle Aged
Mortality
Nosocomial infections
Original Article
Pathogens
Patients
Prognosis
Public health
Retrospective Studies
Sepsis
Sepsis - diagnosis
Sepsis - microbiology
Sepsis - mortality
Software
Statistical analysis
Survival Analysis
Time Factors
Young Adult
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Summary:The purpose of this study was to investigate the relationship between the time to positivity (TTP) of blood cultures and outcome in patients with bloodstream infections (BSIs). Between January 1st, 2011 and December 31st, 2013, the blood cultures of inpatients with BSI or catheter-related BSI were collected at Peking University Third Hospital. The TTP of different isolates was analyzed, and the relationship between the TTP of isolates and outcome of patients with Enterobacter BSI was retrospectively analyzed. We analyzed the TTP of 886 isolates. Escherichia coli has the shortest (11.97 ± 10.06 h) and Candida has the longest first TTP (61.62 ± 42.77 h). 68.01 % of isolates reached positivity within 24 h and 88.33 % within 48 h. Over 90 % of E. coli isolates reached positivity within 24 h. Over 50 % of Candida isolates reached positivity within 48 h. The TTP differed significantly between cultures that were single or double positive for coagulase-negative staphylococci isolates, Enterobacteriaceae, and Pseudomonas aeruginosa , and between aerobic and anaerobic cultures of E. coli ( p  
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-016-2580-5