CASTORing New Light on Amino Acid Sensing

The activation state of mTORC1, a master regulator of cell growth, is particularly sensitive to changes in the intracellular levels of the amino acid arginine, but the sensing mechanisms are poorly understood. In this issue of Cell, Chantranupong et al. identify CASTOR1 as a direct arginine sensor t...

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Bibliographic Details
Published in:Cell 2016-03, Vol.165 (1), p.15-17
Main Authors: Hallett, James E. Hughes, Manning, Brendan D.
Format: Article
Language:English
Subjects:
Amino Acids - metabolism
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Signal Transduction
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Summary:The activation state of mTORC1, a master regulator of cell growth, is particularly sensitive to changes in the intracellular levels of the amino acid arginine, but the sensing mechanisms are poorly understood. In this issue of Cell, Chantranupong et al. identify CASTOR1 as a direct arginine sensor that acts through the GATOR2 complex to regulate mTORC1. The activation state of mTORC1, a master regulator of cell growth, is particularly sensitive to changes in the intracellular levels of the amino acid arginine, but the sensing mechanisms are poorly understood. In this issue of Cell, Chantranupong et al. identify CASTOR1 as a direct arginine sensor that acts through the GATOR2 complex to regulate mTORC1.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2016.03.002