Sex differences in bronchiolar epithelium response after the inhalation of lead acetate (Pb)

In order to identify if there were sex differences in lead (Pb) lung concentrations and in bronchiolar response after its inhalation, a mice inhalation model was conducted. Sixty CD-1 adult mice from each sex inhaled separately, lead acetate 0.1 M for 1 h, thrice weekly during 15 days. Animals were...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2005-02, Vol.207 (2), p.323-330
Main Authors: Fortoul, Teresa Imelda, Moncada-Hernández, Sandra, Saldivar-Osorio, Liliana, Espejel-Maya, Guadalupe, Mussali-Galante, Patricia, Ávila-Casado, Maria del Carmen, Colín-Barenque, Laura, Hernández-Serrato, Maria Isidra, Ávila-Costa, Maria Rosa
Format: Article
Language:English
Subjects:
Administration, Inhalation
Animals
Biological and medical sciences
Bronchi - drug effects
Bronchi - metabolism
Bronchi - ultrastructure
Chemical and industrial products toxicology. Toxic occupational diseases
Epithelium - drug effects
Epithelium - metabolism
Epithelium - ultrastructure
Female
Gender differences
Inhaled metals
Lead - analysis
Lead acetate
Lung - drug effects
Lung - metabolism
Lung - ultrastructure
Male
Medical sciences
Metals and various inorganic compounds
Mice
Mice, Inbred Strains
Microscopy, Electron, Scanning
Models, Animal
Organometallic Compounds - toxicity
Scanning electron microscopy
Sex differences
Sex Factors
Toxicology
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Summary:In order to identify if there were sex differences in lead (Pb) lung concentrations and in bronchiolar response after its inhalation, a mice inhalation model was conducted. Sixty CD-1 adult mice from each sex inhaled separately, lead acetate 0.1 M for 1 h, thrice weekly during 15 days. Animals were evaluated for Pb-lung concentrations by atomic absorption spectrometry and for morphological evaluation by scanning electron microscopy (SEM). Higher Pb-lung concentrations were determined in females, however, more cell damage was found in males, finding that correlated with an increased loss of the nonciliated bronchiolar cells (NCBC) more sloughing and necrosis. Differences in particle clearance, oxidative stress handling, cytokines pathway activation and cytochrome P450 enzymes activity, all influenced by sex hormones, might be a possible explanation for our findings. The relevance of further studies in this field is stressed, as well as its relation to the different development expected for each sex in disease evolution, possible complications and treatment response.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2004.10.004