Exhaled Nitric Oxide: A Novel Biomarker of Adverse Respiratory Health Effects in Epidemiological Studies

The sampling of exhaled breath is a noninvasive procedure that can be performed easily in adults, children, and patients with respiratory disease. Several studies have demonstrated increased exhaled nitric oxide in patients with pulmonary disease, including asthma. In addition, exhaled nitric oxide...

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Bibliographic Details
Published in:Archives of environmental health 2000-11, Vol.55 (6), p.418-423
Main Authors: van Amsterdam, Jan G.C., Nierkens, Stefan, Vos, Sjef G., Opperhuizen, Antoon, Loveren, Henkvan, Steerenberg, Peter A.
Format: Article
Language:English
Subjects:
air pollution
allergy
asthma
Biological and medical sciences
biomarker
Biomarkers - analysis
Breath Tests
Confounding Factors (Epidemiology)
Environmental Monitoring - methods
Environmental Pollutants - adverse effects
Environmental Pollutants - analysis
Epidemiologic Methods
Epidemiological Monitoring
Epidemiology
exhaled air
General aspects
Humans
Life Style
Lung Diseases - diagnosis
Lung Diseases - etiology
Medical sciences
Methodology
nitric oxide
Nitric Oxide - analysis
Public health. Hygiene
Public health. Hygiene-occupational medicine
respiratory tract diseases
Sensitivity and Specificity
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Summary:The sampling of exhaled breath is a noninvasive procedure that can be performed easily in adults, children, and patients with respiratory disease. Several studies have demonstrated increased exhaled nitric oxide in patients with pulmonary disease, including asthma. In addition, exhaled nitric oxide may be an elegant tool for monitoring of environmental health effects of air pollution and the prevalence of atopy in epidemiological surveys. Recent literature about exhaled nitric oxide is presented in this article. Technical, physiological, and behavioral confounding factors of exhaled nitric oxide measurement are outlined.
ISSN:0003-9896
2331-4303
DOI:10.1080/00039890009604040