Impact of stereotactic radiotherapy on kidney function in primary renal cell carcinoma: Establishing a dose–response relationship

Abstract Background and purpose To evaluate renal dysfunction after stereotactic ablative body radiotherapy (SABR) for inoperable primary renal cell carcinoma (RCC) using nuclear medicine assessments. Materials and methods In a prospective clinical trial, patients received single fraction renal SABR...

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Bibliographic Details
Published in:Radiotherapy and oncology 2016-03, Vol.118 (3), p.540-546
Main Authors: Siva, Shankar, Jackson, Price, Kron, Tomas, Bressel, Mathias, Lau, Eddie, Hofman, Michael, Shaw, Mark, Chander, Sarat, Pham, Daniel, Lawrentschuk, Nathan, Wong, Lih-Ming, Goad, Jeremy, Foroudi, Farshad
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Renal Cell - physiopathology
Carcinoma, Renal Cell - surgery
Creatinine
Female
Glomerular Filtration Rate - radiation effects
Hematology, Oncology and Palliative Medicine
Humans
Kidney - physiopathology
Kidney - radiation effects
Kidney - surgery
Kidney Neoplasms - physiopathology
Kidney Neoplasms - surgery
Male
Middle Aged
Nephron sparing
Normal tissue toxicity
Prospective Studies
Radiosurgery - adverse effects
Radiosurgery - methods
RCC
SABR
SBRT
Tomography, Emission-Computed, Single-Photon
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Summary:Abstract Background and purpose To evaluate renal dysfunction after stereotactic ablative body radiotherapy (SABR) for inoperable primary renal cell carcinoma (RCC) using nuclear medicine assessments. Materials and methods In a prospective clinical trial, patients received single fraction renal SABR (26 Gy) for tumours 50% isodoses) may help reduce risk of functional loss.
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2016.01.027