An EM-like reconstruction method for diffuse optical tomography

• Published in: International journal for numerical methods in biomedical engineering 2010-09, Vol.26 (9), p.1099-1116
• Main Author: Wang, Caifang
• Format: Article
• Language: English
• Subjects: absorption coefficient; Algorithms; Applied sciences; Artificial intelligence; Biological and medical sciences; Boundaries; Computer science; control theory; systems; diffuse optical tomography (DOT); Diffusion; diffusion coefficient; Exact sciences and technology; Investigative techniques, diagnostic techniques (general aspects); Iterative methods; Kuhn-Tucker condition; Mathematical analysis; Mathematical models; Medical sciences; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Pattern recognition. Digital image processing. Computational geometry; Poissonian noise; Reconstruction; Tomography
• ISSN: 2040-7939; 2040-7947; 2040-7947
• DOI: 10.1002/cnm.1387

Diffuse optical tomography (DOT) is an optical imaging modality which provides the spatial distributions of optical parameters inside an object. The forward model of DOT is described by the diffusion approximation of radiative transfer equation, while the DOT is to reconstruct the optical parameters from boundary measurements. In this paper, an EM‐like iterative reconstruction method specifically for the steady state DOT problem is developed. Previous iterative reconstruction methods are mostly based on the assumption that the measurement noise is Gaussian, and are of least‐squares type. In this paper, with the assumption that the boundary measurements have independent and identical Poisson distributions, the inverse problem of DOT is solved by maximizing a log‐likelihood functional with inequality constraints, and then an EM‐like reconstruction algorithm is developed according to the Kuhn–Tucker condition. The proposed algorithm is a variant of the well‐known EM algorithm. The performance of the proposed algorithm is tested with three‐dimensional numerical simulation. Copyright © 2010 John Wiley & Sons, Ltd.