The Pleiotropic Effect of Glycodelin-A in Early Pregnancy

Successful pregnancy depends largely on adequate placentation and maternal tolerance of the fetus. Glycodelin‐A is a glycoprotein abundant in the decidua during early pregnancy. It plays an important role in placental development and fetomaternal defense. Glycodelin‐A interacts by its unique carbohy...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2016-03, Vol.75 (3), p.290-297
Main Authors: Lee, Cheuk-Lun, Lam, Kevin K. W., Vijayan, Madhavi, Koistinen, Hannu, Seppala, Markku, Ng, Ernest H. Y., Yeung, William S. B., Chiu, Philip C. N.
Format: Article
Language:English
Subjects:
Abortion, Habitual - blood
Abortion, Habitual - immunology
Animals
Decidua - immunology
Decidua - metabolism
Female
Fetomaternal tolerance
Glycodelin
glycodelin-A
Glycoproteins - blood
Glycoproteins - immunology
glycosylation
Humans
Infertility, Female - blood
Maternal-Fetal Exchange - immunology
Miscarriage
placentation
preeclampsia
Pregnancy
Pregnancy - blood
Pregnancy - immunology
Trophoblasts - immunology
Trophoblasts - metabolism
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Summary:Successful pregnancy depends largely on adequate placentation and maternal tolerance of the fetus. Glycodelin‐A is a glycoprotein abundant in the decidua during early pregnancy. It plays an important role in placental development and fetomaternal defense. Glycodelin‐A interacts by its unique carbohydrate side chains with the cell surface of various cell types in the human fetomaternal interface, particularly the trophoblasts and the immune cells, and modulates their functions and differentiation to permit successful pregnancy. Abnormal levels of glycodelin‐A in the endometrium, uterine flushings, and/or maternal serum correlate with unexplained infertility, early pregnancy loss, and recurrent miscarriage. This review integrates recent studies on the role of glycodelin‐A in placental development and fetomaternal tolerance in early pregnancy.
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.12471