Age- and sex-specific association of circulating osteocalcin with dynamic measures of glucose homeostasis

Summary Our study showed that serum osteocalcin levels are closely related to glucose metabolism in men of all ages and younger women. This association disappeared in postmenopausal women in which increases bone turnover rates. The association between serum osteocalcin levels and glucose homeostasis...

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Bibliographic Details
Published in:Osteoporosis international 2016-03, Vol.27 (3), p.1021-1029
Main Authors: Jung, K. Y., Kim, K. M., Ku, E. J., Kim, Y. J., Lee, D.-H., Choi, S. H., Jang, H. C., Shin, C. S., Park, K. S., Lim, S.
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Aging - blood
Anthropometry - methods
Blood Glucose - metabolism
Cross-Sectional Studies
Endocrinology
Female
Gender
Glucose
Glucose Tolerance Test - methods
Glycated Hemoglobin A - analysis
Homeostasis - physiology
Humans
Insulin resistance
Insulin Resistance - physiology
Male
Medicine
Medicine & Public Health
Metabolism
Middle Aged
Original Article
Orthopedics
Osteocalcin - blood
Rheumatology
Sex Characteristics
Young Adult
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Summary:Summary Our study showed that serum osteocalcin levels are closely related to glucose metabolism in men of all ages and younger women. This association disappeared in postmenopausal women in which increases bone turnover rates. The association between serum osteocalcin levels and glucose homeostasis should be interpreted according to age and sex. Introduction Osteocalcin, a marker of bone formation, appears to be associated with glucose homeostasis. We investigated the age- and sex-specific association of serum osteocalcin level with variables related to glucose metabolism. Methods This study was based on cross-sectional analysis from 719 participants aged 20–85 years after excluding patients taking antidiabetic or antiosteoporotic drugs. The subjects were divided into four groups according to age and sex as follows: men
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-015-3315-7