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Age- and sex-specific association of circulating osteocalcin with dynamic measures of glucose homeostasis
Summary Our study showed that serum osteocalcin levels are closely related to glucose metabolism in men of all ages and younger women. This association disappeared in postmenopausal women in which increases bone turnover rates. The association between serum osteocalcin levels and glucose homeostasis...
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| Published in: | Osteoporosis international 2016-03, Vol.27 (3), p.1021-1029 |
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| container_end_page | 1029 |
| container_issue | 3 |
| container_start_page | 1021 |
| container_title | Osteoporosis international |
| container_volume | 27 |
| creator | Jung, K. Y. Kim, K. M. Ku, E. J. Kim, Y. J. Lee, D.-H. Choi, S. H. Jang, H. C. Shin, C. S. Park, K. S. Lim, S. |
| description | Summary
Our study showed that serum osteocalcin levels are closely related to glucose metabolism in men of all ages and younger women. This association disappeared in postmenopausal women in which increases bone turnover rates. The association between serum osteocalcin levels and glucose homeostasis should be interpreted according to age and sex.
Introduction
Osteocalcin, a marker of bone formation, appears to be associated with glucose homeostasis. We investigated the age- and sex-specific association of serum osteocalcin level with variables related to glucose metabolism.
Methods
This study was based on cross-sectional analysis from 719 participants aged 20–85 years after excluding patients taking antidiabetic or antiosteoporotic drugs. The subjects were divided into four groups according to age and sex as follows: men |
| doi_str_mv | 10.1007/s00198-015-3315-7 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1776645818</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1768564399</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-60ee0112d20272d6cdb857acd4923e43f90fec0029d73d771ed1a16eeb22ee0d3</originalsourceid><addsrcrecordid>eNqNkU1rFTEUhoMo9rb6A9xIwI2baD4myWRZil9Q6KaF7kJucuY2ZWZyzZnB9t-by60iguAmh3Ce5w3hJeSN4B8E5_Yjci5cz7jQTKl22GdkIzqlmHRGPycb7pRlrhO3J-QU8Z43xzn7kpxIo6xyvdqQfL4DRsOcKMIDwz3EPORIA2KJOSy5zLQMNOYa17Fd5x0tuECJYYx5pj_yckfT4xym5kwQcK2AB2E3rrEg0LsyQRMCZnxFXgxhRHj9NM_IzedP1xdf2eXVl28X55csdlYvzHAALoRMkksrk4lp22sbYuqcVNCpwfEBIufSJauStQKSCMIAbKVsZlJn5P0xd1_L9xVw8VPGCOMYZigremGtMZ3uRf8fqOm16ZRzDX33F3pf1jq3j3jRS6eNlp1ulDhSsRbECoPf1zyF-ugF94fK_LEy3yrzh8q8bc7bp-R1O0H6bfzqqAHyCGBbzTuofzz9z9SfN_2h4g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1829565245</pqid></control><display><type>article</type><title>Age- and sex-specific association of circulating osteocalcin with dynamic measures of glucose homeostasis</title><source>Springer Link</source><creator>Jung, K. Y. ; Kim, K. M. ; Ku, E. J. ; Kim, Y. J. ; Lee, D.-H. ; Choi, S. H. ; Jang, H. C. ; Shin, C. S. ; Park, K. S. ; Lim, S.</creator><creatorcontrib>Jung, K. Y. ; Kim, K. M. ; Ku, E. J. ; Kim, Y. J. ; Lee, D.-H. ; Choi, S. H. ; Jang, H. C. ; Shin, C. S. ; Park, K. S. ; Lim, S.</creatorcontrib><description><![CDATA[Summary
Our study showed that serum osteocalcin levels are closely related to glucose metabolism in men of all ages and younger women. This association disappeared in postmenopausal women in which increases bone turnover rates. The association between serum osteocalcin levels and glucose homeostasis should be interpreted according to age and sex.
Introduction
Osteocalcin, a marker of bone formation, appears to be associated with glucose homeostasis. We investigated the age- and sex-specific association of serum osteocalcin level with variables related to glucose metabolism.
Methods
This study was based on cross-sectional analysis from 719 participants aged 20–85 years after excluding patients taking antidiabetic or antiosteoporotic drugs. The subjects were divided into four groups according to age and sex as follows: men <50 years (
n
= 131), men ≥50 years (
n
= 191), women <50 years (
n
= 108), and women ≥50 years (
n
= 279). Anthropometric and biochemical variables including insulin resistance (HOMA-IR) and β cell function (HOMA-β) from a 75-g oral glucose tolerance test, and serum 25-OH-vitamin D and parathyroid hormone levels were measured.
Results
The serum osteocalcin level was significantly higher in women aged ≥50 years compared with women <50 years (20.4 ± 7.8 vs. 17.9 ± 6.8 ng/ml,
p
< 0.001), but there was no difference between men aged ≥50 years and men <50 years (16.4 ± 5.9 vs. 16.8 ± 6.0 ng/ml,
p
= 0.905). The participants diagnosed with diabetes had lower serum osteocalcin levels than normal or prediabetic participants. Multivariable regression analyses including HOMA-IR and HOMA-β indicated that serum osteocalcin levels had a negative and independent association with HbA1c levels in men and women aged <50 years, but not in women ≥50 years.
Conclusions
Low osteocalcin levels are associated with impaired glucose metabolism in men and premenopausal women. The osteocalcin levels may be determined by factors related to bone metabolism in postmenopausal women. Our data suggest that the serum levels of osteocalcin associated with glucose homeostasis should be interpreted according to age and sex.]]></description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-015-3315-7</identifier><identifier>PMID: 26373983</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Adult ; Age ; Aged ; Aged, 80 and over ; Aging - blood ; Anthropometry - methods ; Blood Glucose - metabolism ; Cross-Sectional Studies ; Endocrinology ; Female ; Gender ; Glucose ; Glucose Tolerance Test - methods ; Glycated Hemoglobin A - analysis ; Homeostasis - physiology ; Humans ; Insulin resistance ; Insulin Resistance - physiology ; Male ; Medicine ; Medicine & Public Health ; Metabolism ; Middle Aged ; Original Article ; Orthopedics ; Osteocalcin - blood ; Rheumatology ; Sex Characteristics ; Young Adult</subject><ispartof>Osteoporosis international, 2016-03, Vol.27 (3), p.1021-1029</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2015</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-60ee0112d20272d6cdb857acd4923e43f90fec0029d73d771ed1a16eeb22ee0d3</citedby><cites>FETCH-LOGICAL-c475t-60ee0112d20272d6cdb857acd4923e43f90fec0029d73d771ed1a16eeb22ee0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26373983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, K. Y.</creatorcontrib><creatorcontrib>Kim, K. M.</creatorcontrib><creatorcontrib>Ku, E. J.</creatorcontrib><creatorcontrib>Kim, Y. J.</creatorcontrib><creatorcontrib>Lee, D.-H.</creatorcontrib><creatorcontrib>Choi, S. H.</creatorcontrib><creatorcontrib>Jang, H. C.</creatorcontrib><creatorcontrib>Shin, C. S.</creatorcontrib><creatorcontrib>Park, K. S.</creatorcontrib><creatorcontrib>Lim, S.</creatorcontrib><title>Age- and sex-specific association of circulating osteocalcin with dynamic measures of glucose homeostasis</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description><![CDATA[Summary
Our study showed that serum osteocalcin levels are closely related to glucose metabolism in men of all ages and younger women. This association disappeared in postmenopausal women in which increases bone turnover rates. The association between serum osteocalcin levels and glucose homeostasis should be interpreted according to age and sex.
Introduction
Osteocalcin, a marker of bone formation, appears to be associated with glucose homeostasis. We investigated the age- and sex-specific association of serum osteocalcin level with variables related to glucose metabolism.
Methods
This study was based on cross-sectional analysis from 719 participants aged 20–85 years after excluding patients taking antidiabetic or antiosteoporotic drugs. The subjects were divided into four groups according to age and sex as follows: men <50 years (
n
= 131), men ≥50 years (
n
= 191), women <50 years (
n
= 108), and women ≥50 years (
n
= 279). Anthropometric and biochemical variables including insulin resistance (HOMA-IR) and β cell function (HOMA-β) from a 75-g oral glucose tolerance test, and serum 25-OH-vitamin D and parathyroid hormone levels were measured.
Results
The serum osteocalcin level was significantly higher in women aged ≥50 years compared with women <50 years (20.4 ± 7.8 vs. 17.9 ± 6.8 ng/ml,
p
< 0.001), but there was no difference between men aged ≥50 years and men <50 years (16.4 ± 5.9 vs. 16.8 ± 6.0 ng/ml,
p
= 0.905). The participants diagnosed with diabetes had lower serum osteocalcin levels than normal or prediabetic participants. Multivariable regression analyses including HOMA-IR and HOMA-β indicated that serum osteocalcin levels had a negative and independent association with HbA1c levels in men and women aged <50 years, but not in women ≥50 years.
Conclusions
Low osteocalcin levels are associated with impaired glucose metabolism in men and premenopausal women. The osteocalcin levels may be determined by factors related to bone metabolism in postmenopausal women. Our data suggest that the serum levels of osteocalcin associated with glucose homeostasis should be interpreted according to age and sex.]]></description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - blood</subject><subject>Anthropometry - methods</subject><subject>Blood Glucose - metabolism</subject><subject>Cross-Sectional Studies</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Gender</subject><subject>Glucose</subject><subject>Glucose Tolerance Test - methods</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteocalcin - blood</subject><subject>Rheumatology</subject><subject>Sex Characteristics</subject><subject>Young Adult</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkU1rFTEUhoMo9rb6A9xIwI2baD4myWRZil9Q6KaF7kJucuY2ZWZyzZnB9t-by60iguAmh3Ce5w3hJeSN4B8E5_Yjci5cz7jQTKl22GdkIzqlmHRGPycb7pRlrhO3J-QU8Z43xzn7kpxIo6xyvdqQfL4DRsOcKMIDwz3EPORIA2KJOSy5zLQMNOYa17Fd5x0tuECJYYx5pj_yckfT4xym5kwQcK2AB2E3rrEg0LsyQRMCZnxFXgxhRHj9NM_IzedP1xdf2eXVl28X55csdlYvzHAALoRMkksrk4lp22sbYuqcVNCpwfEBIufSJauStQKSCMIAbKVsZlJn5P0xd1_L9xVw8VPGCOMYZigremGtMZ3uRf8fqOm16ZRzDX33F3pf1jq3j3jRS6eNlp1ulDhSsRbECoPf1zyF-ugF94fK_LEy3yrzh8q8bc7bp-R1O0H6bfzqqAHyCGBbzTuofzz9z9SfN_2h4g</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Jung, K. Y.</creator><creator>Kim, K. M.</creator><creator>Ku, E. J.</creator><creator>Kim, Y. J.</creator><creator>Lee, D.-H.</creator><creator>Choi, S. H.</creator><creator>Jang, H. C.</creator><creator>Shin, C. S.</creator><creator>Park, K. S.</creator><creator>Lim, S.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160301</creationdate><title>Age- and sex-specific association of circulating osteocalcin with dynamic measures of glucose homeostasis</title><author>Jung, K. Y. ; Kim, K. M. ; Ku, E. J. ; Kim, Y. J. ; Lee, D.-H. ; Choi, S. H. ; Jang, H. C. ; Shin, C. S. ; Park, K. S. ; Lim, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-60ee0112d20272d6cdb857acd4923e43f90fec0029d73d771ed1a16eeb22ee0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - blood</topic><topic>Anthropometry - methods</topic><topic>Blood Glucose - metabolism</topic><topic>Cross-Sectional Studies</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Gender</topic><topic>Glucose</topic><topic>Glucose Tolerance Test - methods</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteocalcin - blood</topic><topic>Rheumatology</topic><topic>Sex Characteristics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, K. Y.</creatorcontrib><creatorcontrib>Kim, K. M.</creatorcontrib><creatorcontrib>Ku, E. J.</creatorcontrib><creatorcontrib>Kim, Y. J.</creatorcontrib><creatorcontrib>Lee, D.-H.</creatorcontrib><creatorcontrib>Choi, S. H.</creatorcontrib><creatorcontrib>Jang, H. C.</creatorcontrib><creatorcontrib>Shin, C. S.</creatorcontrib><creatorcontrib>Park, K. S.</creatorcontrib><creatorcontrib>Lim, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Physical Education Index</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, K. Y.</au><au>Kim, K. M.</au><au>Ku, E. J.</au><au>Kim, Y. J.</au><au>Lee, D.-H.</au><au>Choi, S. H.</au><au>Jang, H. C.</au><au>Shin, C. S.</au><au>Park, K. S.</au><au>Lim, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age- and sex-specific association of circulating osteocalcin with dynamic measures of glucose homeostasis</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>27</volume><issue>3</issue><spage>1021</spage><epage>1029</epage><pages>1021-1029</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract><![CDATA[Summary
Our study showed that serum osteocalcin levels are closely related to glucose metabolism in men of all ages and younger women. This association disappeared in postmenopausal women in which increases bone turnover rates. The association between serum osteocalcin levels and glucose homeostasis should be interpreted according to age and sex.
Introduction
Osteocalcin, a marker of bone formation, appears to be associated with glucose homeostasis. We investigated the age- and sex-specific association of serum osteocalcin level with variables related to glucose metabolism.
Methods
This study was based on cross-sectional analysis from 719 participants aged 20–85 years after excluding patients taking antidiabetic or antiosteoporotic drugs. The subjects were divided into four groups according to age and sex as follows: men <50 years (
n
= 131), men ≥50 years (
n
= 191), women <50 years (
n
= 108), and women ≥50 years (
n
= 279). Anthropometric and biochemical variables including insulin resistance (HOMA-IR) and β cell function (HOMA-β) from a 75-g oral glucose tolerance test, and serum 25-OH-vitamin D and parathyroid hormone levels were measured.
Results
The serum osteocalcin level was significantly higher in women aged ≥50 years compared with women <50 years (20.4 ± 7.8 vs. 17.9 ± 6.8 ng/ml,
p
< 0.001), but there was no difference between men aged ≥50 years and men <50 years (16.4 ± 5.9 vs. 16.8 ± 6.0 ng/ml,
p
= 0.905). The participants diagnosed with diabetes had lower serum osteocalcin levels than normal or prediabetic participants. Multivariable regression analyses including HOMA-IR and HOMA-β indicated that serum osteocalcin levels had a negative and independent association with HbA1c levels in men and women aged <50 years, but not in women ≥50 years.
Conclusions
Low osteocalcin levels are associated with impaired glucose metabolism in men and premenopausal women. The osteocalcin levels may be determined by factors related to bone metabolism in postmenopausal women. Our data suggest that the serum levels of osteocalcin associated with glucose homeostasis should be interpreted according to age and sex.]]></abstract><cop>London</cop><pub>Springer London</pub><pmid>26373983</pmid><doi>10.1007/s00198-015-3315-7</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Osteoporosis international, 2016-03, Vol.27 (3), p.1021-1029 |
| issn | 0937-941X 1433-2965 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1776645818 |
| source | Springer Link |
| subjects | Adult Age Aged Aged, 80 and over Aging - blood Anthropometry - methods Blood Glucose - metabolism Cross-Sectional Studies Endocrinology Female Gender Glucose Glucose Tolerance Test - methods Glycated Hemoglobin A - analysis Homeostasis - physiology Humans Insulin resistance Insulin Resistance - physiology Male Medicine Medicine & Public Health Metabolism Middle Aged Original Article Orthopedics Osteocalcin - blood Rheumatology Sex Characteristics Young Adult |
| title | Age- and sex-specific association of circulating osteocalcin with dynamic measures of glucose homeostasis |
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