Management of Candida biofilms: state of knowledge and new options for prevention and eradication

Biofilms formed by Candida species (spp.) on medical devices represent a potential health risk. The focus of current research is searching for new options for the treatment and prevention of biofilm-associated infections using different approaches including modern nanotechnology. This review summari...

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Bibliographic Details
Published in:Future microbiology 2016-01, Vol.11 (2), p.235-251
Main Author: Bujdakova, Helena
Format: Article
Language:English
Subjects:
Antifungal Agents - therapeutic use
Antimicrobial Cationic Peptides - therapeutic use
Biofilms
Biofilms - drug effects
Biofilms - growth & development
Candida
Candida - drug effects
Candida - physiology
Candida albicans
Candida albicans - drug effects
Candida albicans - physiology
Candidiasis - prevention & control
Candidiasis - therapy
Carbohydrates
Catheters
Disease Management
Drug resistance
Drug Resistance, Fungal - genetics
Extracellular matrix
Health risks
Humans
Inactivation
Infections
Medical equipment
Microbial Sensitivity Tests
Microorganisms
Morphology
Nanotechnology
Photochemotherapy
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Summary:Biofilms formed by Candida species (spp.) on medical devices represent a potential health risk. The focus of current research is searching for new options for the treatment and prevention of biofilm-associated infections using different approaches including modern nanotechnology. This review summarizes current information concerning the most relevant resistance/tolerance mechanisms to conventional drugs and a role of additional factors contributing to these phenomena in Candida spp. (mostly Candida albicans). Additionally, it provides an information update in prevention and eradication of a Candida biofilm including experiences with 'lock' therapy, potential utilization of small molecules in biomedical applications, and perspectives of using photodynamic inactivation in the control of a Candida biofilm.
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb.15.139