Increased complexin-1 and decreased miR-185 expression levels in Behçet’s disease with and without neurological involvement

Although complexin 1 (CPLX1) is not known as an inflammation factor, recent identification of a complexin 1 (CPLX1) polymorphism in Behçet’s disease (BD) has sparked an interest in the role of this molecule in autoinflammation. DNA samples were isolated from peripheral blood mononuclear cells (PBMC)...

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Bibliographic Details
Published in:Neurological sciences 2016-03, Vol.37 (3), p.411-416
Main Authors: Uğurel, Elif, Şehitoğlu, Elçin, Tüzün, Erdem, Kürtüncü, Murat, Çoban, Arzu, Vural, Burçak
Format: Article
Language:English
Subjects:
Adaptor Proteins, Vesicular Transport - blood
Adaptor Proteins, Vesicular Transport - genetics
Adolescent
Adult
Behcet Syndrome - blood
Behcet Syndrome - genetics
Female
Genotyping Techniques
Humans
Leukocytes, Mononuclear - metabolism
Male
Medicine
Medicine & Public Health
MicroRNAs - blood
MicroRNAs - genetics
Middle Aged
Nerve Tissue Proteins - blood
Nerve Tissue Proteins - genetics
Nervous System Diseases - blood
Nervous System Diseases - genetics
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Original Article
Polymorphism, Single Nucleotide
Psychiatry
Real-Time Polymerase Chain Reaction
Severity of Illness Index
Young Adult
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Summary:Although complexin 1 (CPLX1) is not known as an inflammation factor, recent identification of a complexin 1 (CPLX1) polymorphism in Behçet’s disease (BD) has sparked an interest in the role of this molecule in autoinflammation. DNA samples were isolated from peripheral blood mononuclear cells (PBMC) of BD and neuro-Behçet’s disease (NBD) patients and expression levels of CPLX1 and miR-185, a predicted target miRNA for CPLX1 and an inflammation-related miRNA, were investigated by real time PCR assays. PBMC expression levels of CPLX1 were significantly increased in BD and NBD patients. By contrast, levels of miR-185 were reduced in both patient groups. A moderate inverse correlation was found between levels of CPLX1 and miR-185. No correlation could be found between expression levels and clinical features of patients. Significant expression alterations of CPLX1 in BD and NBD patients suggest that this molecule has a proinflammatory action. The putative role of CPLX1 in BD pathogenesis remains to be further studied.
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-015-2419-3