Factors affecting breast milk composition and potential consequences for development of the allergic phenotype

Summary There is conflicting evidence on the protective role of breastfeeding in relation to allergic sensitization and disease. The factors in breast milk which influence these processes are still unclear and under investigation. We know that colostrum and breast milk contain a variety of molecules...

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Bibliographic Details
Published in:Clinical and experimental allergy 2015-03, Vol.45 (3), p.583-601
Main Authors: Munblit, D., Boyle, R. J., Warner, J. O.
Format: Article
Language:English
Subjects:
Breast Feeding
Breastfeeding & lactation
Colostrum - immunology
Environment
Genotype & phenotype
Humans
Hypersensitivity - etiology
Hypersensitivity - immunology
Immunity
Infant
Infant, Newborn
Milk
Milk, Human - chemistry
Milk, Human - immunology
Milk, Human - microbiology
Phenotype
Risk
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Summary:Summary There is conflicting evidence on the protective role of breastfeeding in relation to allergic sensitization and disease. The factors in breast milk which influence these processes are still unclear and under investigation. We know that colostrum and breast milk contain a variety of molecules which can influence immune responses in the gut‐associated lymphoid tissue of a neonate. This review summarizes the evidence that variations in colostrum and breast milk composition can influence allergic outcomes in the infant, and the evidence that maternal and environmental factors can modify milk composition. Taken together, the data presented support the possibility that maternal dietary interventions may be an effective way to promote infant health through modification of breast milk composition.
ISSN:0954-7894
1365-2222
DOI:10.1111/cea.12381