Twenty five years since the first prospective study by Forman et al. (1991) on Helicobacter pylori and stomach cancer risk

Highlights • The link between Helicobacter pylori and stomach cancer was first reported in 1991. • 9 out of 10 non-cardia gastric cancers worldwide are attributed to H. pylori infection. • Since then treatment of peptic ulcer disease incorporates the use of a proton pump inhibitor and two antibiotic...

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Bibliographic Details
Published in:Cancer epidemiology 2016-04, Vol.41, p.159-164
Main Author: Sitas, Freddy
Format: Article
Language:English
Subjects:
Bacteria
Bacterial infections
Cancer
Chronic illnesses
Discovery
Duodenal Ulcer - microbiology
Epidemiology
Gastric cancer
Gastritis - microbiology
Helicobacter Infections - complications
Helicobacter pylori
Helicobacter pylori - isolation & purification
Hematology, Oncology and Palliative Medicine
Hospitals
Humans
Immunoglobulins
Incidence
Infections
Internal Medicine
Laboratories
Mortality
Nitrates
Pathogenesis
Prevalence
Review
Risk
Stomach cancer
Stomach Neoplasms - epidemiology
Stomach Neoplasms - microbiology
Studies
Ulcers
Vaccines
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Summary:Highlights • The link between Helicobacter pylori and stomach cancer was first reported in 1991. • 9 out of 10 non-cardia gastric cancers worldwide are attributed to H. pylori infection. • Since then treatment of peptic ulcer disease incorporates the use of a proton pump inhibitor and two antibiotics. • A decline in the prevalence of H. pylori has been noted across time, with concomitant declines in peptic ulcer disease and gastric cancer. • A newly developed oral vaccine against H. pylori holds hope of being the third vaccine against a cancer causing infection.
ISSN:1877-7821
1877-783X
DOI:10.1016/j.canep.2016.02.002