Oxytocin Receptor Genetic and Epigenetic Variations: Association With Child Abuse and Adult Psychiatric Symptoms

• Published in: Child development 2016-01, Vol.87 (1), p.122-134
• Main Authors: Smearman, Erica L., Almli, Lynn M., Conneely, Karen N., Brody, Gene H., Sales, Jessica M., Bradley, Bekh, Ressler, Kerry J., Smith, Alicia K.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Adult Survivors of Child Abuse; Adults; African Americans; African Americans - genetics; African Americans - psychology; Aged; Anxiety; Anxiety - etiology; Anxiety - genetics; Anxiety-Depression; Child & adolescent psychiatry; Child Abuse; Child abuse & neglect; Childhood; Children; Correlation; CpG Islands; Deoxyribonucleic acid; Depression; Depression (Psychology); Depression - etiology; Depression - genetics; DNA; DNA methylation; DNA Methylation - genetics; DNA structure; Epigenesis, Genetic - genetics; Epigenetics; Female; Gene expression; Genes; Genetic diversity; Genetics; Genotype; Genotype & phenotype; Genotypes; Hormones; Humans; Male; Mental depression; Mental Disorders; Methylation; Middle Aged; Oxytocin; Physiology; Polymorphism, Single Nucleotide; Prediction; Psychiatric symptoms; Psychiatry; Psychopathology; Receptors, Oxytocin - genetics; Risk; Role; Scientific Research; Single-nucleotide polymorphism; SPECIAL SECTION; Symptoms; Symptoms (Individual Disorders); Young Adult
• ISSN: 0009-3920; 1467-8624
• DOI: 10.1111/cdev.12493

Childhood abuse can alter biological systems and increase risk for adult psychopathology. Epigenetic mechanisms, alterations in DNA structure that regulate the gene expression, are a potential mechanism underlying this risk. While abuse associates with methylation of certain genes, particularly those in the stress response system, no study to date has evaluated abuse and methylation of the oxytocin receptor (OXTR). However, studies support a role for OXTR in the link between abuse and adverse adult outcomes, showing that abuse can confer greater risk for psychiatric symptoms in those with specific OXTR genotypes. This study therefore sought to (a) assess the role of epigenetics in the link between abuse and psychopathology and (b) begin to integrate the genetic and epigenetic literature by exploring associations between OXTR genotypes and DNA CpG methylation. Data on 18 OXTR CpG sites, 44 single nucleotide polymorphisms, childhood abuse, and adult depression and anxiety symptoms were assessed in 393 African American adults (age = 41 ± 12.8 years). Overall, 68% of genotypes were associated with methylation of nearby CpG sites, with a subset surviving multiple test correction. Child abuse associated with higher methylation of two CpG sites yet did not survive correction or serve as a mediator of psychopathology. However, abuse interacted with CpG methylation to predict psychopathology. These findings suggest a role for OXTR in understanding the influence of early environments on adult psychiatric symptoms.