HIV reservoirs: what, where and how to target them

Viral reservoirs pose a major challenge in the efforts towards curing HIV. Here, Churchill, Deeks, Margolis, Siliciano and Swanstrom discuss the cells and tissues that constitute the viral reservoir, how best to measure it and how to target this source of persistent infection. One of the main challe...

Full description

Saved in:
Bibliographic Details
Published in:Nature reviews. Microbiology 2016-01, Vol.14 (1), p.55-60
Main Authors: Churchill, Melissa J., Deeks, Steven G., Margolis, David M., Siliciano, Robert F., Swanstrom, Ronald
Format: Article
Language:English
Subjects:
631/250/255/1901
631/326/596/1787
631/326/596/2564
Anti-HIV Agents - therapeutic use
Antiretroviral agents
Beliefs, opinions and attitudes
Biomedical and Life Sciences
Care and treatment
Complications and side effects
Development and progression
Health aspects
Highly active antiretroviral therapy
HIV - drug effects
HIV - physiology
HIV infections
HIV Infections - drug therapy
HIV Infections - virology
Host-virus relationships
Human immunodeficiency virus
Humans
Immune system
Infectious Diseases
Life Sciences
Medical Microbiology
Medical research
Methods
Microbiology
Models, Animal
Molecular targeted therapy
Observations
Parasitology
Patient outcomes
Physicians
Proviruses - drug effects
Proviruses - physiology
viewpoint
Virology
Virulence (Microbiology)
Virus Integration
Virus Latency - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Viral reservoirs pose a major challenge in the efforts towards curing HIV. Here, Churchill, Deeks, Margolis, Siliciano and Swanstrom discuss the cells and tissues that constitute the viral reservoir, how best to measure it and how to target this source of persistent infection. One of the main challenges in the fight against HIV infection is to develop strategies that are able to eliminate the persistent viral reservoir that harbours integrated, replication-competent provirus within host cellular DNA. This reservoir is resistant to antiretroviral therapy (ART) and to clearance by the immune system of the host; viruses originating from this reservoir lead to rebound viraemia once treatment is stopped, giving rise to new rounds of infection. Several studies have focused on elucidating the cells and tissues that harbour persistent virus, the true size of the reservoir and how best to target it, but these topics are the subject of ongoing debate. In this Viewpoint article, several experts in the field discuss the constitution of the viral reservoir, how best to measure it and the best ways to target this source of persistent infection.
ISSN:1740-1526
1740-1534
DOI:10.1038/nrmicro.2015.5