Zero TE MR bone imaging in the head

• Published in: Magnetic resonance in medicine 2016-01, Vol.75 (1), p.107-114
• Main Authors: Wiesinger, Florian, Sacolick, Laura I., Menini, Anne, Kaushik, Sandeep S., Ahn, Sangtae, Veit-Haibach, Patrick, Delso, Gaspar, Shanbhag, Dattesh D.
• Format: Article
• Language: English
• Subjects: Algorithms; Attenuation; attenuation correction; Bias; bone; Bone imaging; Computed tomography; Correlation analysis; Density; Emission; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Image processing; Image segmentation; Imaging, Three-Dimensional - methods; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Medical imaging; PET/MR; Positron emission; Positron emission tomography; Proton density (concentration); Radiation; Radiation therapy; Reproducibility of Results; Robustness; RUFIS; Scaling; segmentation; Sensitivity and Specificity; Signal Processing, Computer-Assisted; Skull; Skull - anatomy & histology; Tissues; UTE; zero TE; ZTE
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/mrm.25545

Purpose To investigate proton density (PD)‐weighted zero TE (ZT) imaging for morphological depiction and segmentation of cranial bone structures. Methods A rotating ultra‐fast imaging sequence (RUFIS) type ZT pulse sequence was developed and optimized for 1) efficient capture of short T2 bone signals and 2) flat PD response for soft‐tissues. An inverse logarithmic image scaling (i.e., −log(image)) was used to highlight bone and differentiate it from surrounding soft‐tissue and air. Furthermore, a histogram‐based bias‐correction method was developed for subsequent threshold‐based air, soft‐tissue, and bone segmentation. Results PD‐weighted ZT imaging in combination with an inverse logarithmic scaling was found to provide excellent depiction of cranial bone structures. In combination with bias correction, also excellent segmentation results were achieved. A two‐dimensional histogram analysis demonstrates a strong, approximately linear correlation between inverse log‐scaled ZT and low‐dose CT for Hounsfield units (HU) between −300 HU and 1,500 HU (corresponding to soft‐tissue and bone). Conclusions PD‐weighted ZT imaging provides robust and efficient depiction of bone structures in the head, with an excellent contrast between air, soft‐tissue, and bone. Besides structural bone imaging, the presented method is expected to be of relevance for attenuation correction in positron emission tomography (PET)/MR and MR‐based radiation therapy planning. Magn Reson Med 75:107–114, 2016. © 2015 Wiley Periodicals, Inc.