Oral Inosine Persistently Elevates Plasma antioxidant capacity in Parkinson's disease

ABSTRACT Introduction Higher serum urate predicts slower progression in PD. The aim of this work was to assess whether oral inosine alters antioxidant capacity of plasma or CSF or urinary markers of oxidative injury in early PD. Methods We assayed plasma and CSF antioxidant capacity by ferric‐reduci...

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Bibliographic Details
Published in:Movement disorders 2016-03, Vol.31 (3), p.417-421
Main Authors: Bhattacharyya, Shamik, Bakshi, Rachit, Logan, Robert, Ascherio, Alberto, Macklin, Eric A., Schwarzschild, Michael A.
Format: Article
Language:English
Subjects:
antioxidant
Antioxidants - administration & dosage
Antioxidants - therapeutic use
Disease Progression
Female
Humans
inosine
Inosine - administration & dosage
Inosine - therapeutic use
Male
Middle Aged
Movement disorders
Oxidative Stress - drug effects
Oxidative Stress - physiology
Parkinson Disease - drug therapy
Parkinson's disease
Treatment Outcome
Uric Acid - blood
uric acid/urate
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Summary:ABSTRACT Introduction Higher serum urate predicts slower progression in PD. The aim of this work was to assess whether oral inosine alters antioxidant capacity of plasma or CSF or urinary markers of oxidative injury in early PD. Methods We assayed plasma and CSF antioxidant capacity by ferric‐reducing antioxidant power and measured DNA oxidation adduct 8‐hydroxydeoxyguanosine from urine in Safety of URate Elevation in PD, a randomized, placebo‐controlled trial of oral inosine assessing safety of elevating serum urate from
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.26483