Human neutrophil peptide-1 decreases during ageing in selected Mexican population

Antimicrobial peptide innate immunity plays a central role in the susceptibility to infectious diseases, as has been described extensively in different settings. However, the role that these molecules play in the immunity mediated by polymorphonuclear phagocytes as part of the innate immunity of age...

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Bibliographic Details
Published in:Immunologic research 2016-04, Vol.64 (2), p.445-454
Main Authors: Rivas-Santiago, Bruno, Castañeda-Delgado, Julio E., de Haro-Acosta, Jeny, Torres-Juarez, Flor, Frausto-Lujan, Isabel, Marin-Luevano, Paulina, González-Amaro, Roberto, Enciso-Moreno, Jose A.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging
Aging - genetics
Aging - metabolism
Allergology
alpha-Defensins - genetics
alpha-Defensins - metabolism
Biomedical and Life Sciences
Biomedicine
Female
Gene Expression
Hispanic people
Humans
Immune system
Immunity, Innate
Immunology
Infectious diseases
Interleukin-1 - genetics
Interleukin-1 - metabolism
Internal Medicine
Intracellular Space
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - metabolism
Male
Medicine/Public Health
Neutrophils - immunology
Neutrophils - metabolism
Older people
Original Article
Peptides
Peroxidase - genetics
Peroxidase - metabolism
Phagocytosis
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Summary:Antimicrobial peptide innate immunity plays a central role in the susceptibility to infectious diseases, as has been described extensively in different settings. However, the role that these molecules play in the immunity mediated by polymorphonuclear phagocytes as part of the innate immunity of ageing individuals has not been described. In the present study, we addressed the question whether antimicrobial activity in polymorphonuclear cells from elderly individuals was altered in comparison with young adults. We compared phagocytosis index, bacterial killing efficiency, myeloperoxidase activity and cathelicidin expression. Results showed that there were no statistical differences among groups. However, human neutrophil peptide-1 (HNP-1) was decreased in the elderly individuals group. Results suggest that the decreased HNP-1 production in the polymorphonuclear phagocytes form elderly individuals might have an important participation in the increased susceptibility to infectious diseases.
ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-015-8689-2