Effect of change in sequence of administration of DTwP and Hepatitis B vaccines on perception of pain in infants: A randomized control trial

Abstract Objective This study was designed with objective to study pain response of infants to change in sequence of administration of Hepatitis B and DTwP vaccines. Methods This was a randomized parallel control trial. The study was carried out in the immunization clinic of the Department of Pediat...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2016-04, Vol.34 (15), p.1816-1822
Main Authors: Kumar, Mithilesh, Upadhyay, Amit, Singh, Jeevika, Chhabra, Manika, Singh, Abhishek, Gupta, Navratan Kumar, Bhat, Aditya, Yadav, C.P
Format: Article
Language:English
Subjects:
Allergy and Immunology
Babies
Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage
Double-Blind Method
DTwP vaccine
Female
Heart rate
Hepatitis
Hepatitis B vaccine
Hepatitis B Vaccines - administration & dosage
Hepatitis B virus
Humans
Immunization
Infant
Infants
Male
Modified Facial Coding System (MFCS)
Neonatal Infant Pain Scale (NIPS)
Pain
Pain - prevention & control
Pain Measurement
Vaccination - methods
Vaccines
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Objective This study was designed with objective to study pain response of infants to change in sequence of administration of Hepatitis B and DTwP vaccines. Methods This was a randomized parallel control trial. The study was carried out in the immunization clinic of the Department of Pediatrics, LLRM Medical College, Meerut. One hundred and thirty healthy term infants up to 4 months of age were injected either DTwP vaccine first or Hepatitis B vaccine first, followed one minute later by the other vaccine. Result Baseline characteristics did not differ between the groups. The mean (SD) of AUC of MFCS and NIPS was significantly more in DF group as compared to HF group (for MFCS 25.5 ± 5.4 versus 22.5 ± 5.5, p < 0.01; for NIPS 31.77 ± 5.5 versus 27.64 ± 6.9, p < 0.01). Similarly mean (SD) of AUC of Heart rate and saturation of oxygen showed significant variation in DF group as compared to HF group (for heart rate 591.6 ± 55 versus 559.6 ± 49, p < 0.01; for SpO2 326.4 ± 12 versus 335 ± 8, p < 0.01). Conclusion These results showed that infant experienced lesser pain when Hepatitis B was administered first than when DTwP vaccine was given first.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.02.031