How to Create an Embryo Penetration Route

Numerous past investigations into human implantation have tended to pay attention to the mechanism of embryo adhesion to endometrial cells or embryo invasion into endometrial stromal tissue. For successful pregnancy, however, embryo penetration through the endometrial epithelial cell (EEC) sheet is...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2016-03, Vol.75 (3), p.326-332
Main Authors: Uchida, Hiroshi, Maruyama, Tetsuo, Masuda, Hirotaka, Uchida, Sayaka, Miki, Fumie, Hihara, Hanako, Katakura, Satomi, Yoshimasa, Yushi, Tanaka, Mamoru
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - immunology
Embryo Implantation - immunology
Embryo, Mammalian - immunology
endometrial epithelial cell
Endometrium - cytology
Endometrium - immunology
Epithelial Cells - cytology
Epithelial Cells - immunology
epithelial to mesenchymal transition
Epithelial-Mesenchymal Transition - immunology
Female
Humans
motility
Pregnancy - immunology
steroid hormone
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Summary:Numerous past investigations into human implantation have tended to pay attention to the mechanism of embryo adhesion to endometrial cells or embryo invasion into endometrial stromal tissue. For successful pregnancy, however, embryo penetration through the endometrial epithelial cell (EEC) sheet is also absolutely required. To improve the performance of assisted reproductive technology, implantation studies should also focus on EEC dynamics, in particular, the action of EECs during embryo penetration. Although only EEC apoptosis has been proposed as a mechanism for the formation of the embryo penetration route, we have also recently reported that characteristic EEC collective motion, regulated by the epithelial to mesenchymal transition, also plays a key role in permitting embryo penetration. We review here how EECs form embryo penetration routes in light of our findings.
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.12476