Drug Delivery: Efficient, pH-Triggered Drug Delivery Using a pH-Responsive DNA-Conjugated Gold Nanoparticle (Adv. Healthcare Mater. 2/2013)

A novel pH‐responsive DNA–gold nanoparticle conjugate that has high drug load, resists non‐specific serum protein adsorption and has high endocytotic cellular uptake is developed by Dejian Zhou, Rongjun Chen, and co‐workers on page 275. Upon acidification in intracellular endosomes/lysosomes, the fo...

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Bibliographic Details
Published in:Advanced healthcare materials 2013-02, Vol.2 (2), p.380-380
Main Authors: Song, Lei, Ho, Vincent H.B., Chen, Chun, Yang, Zhongqiang, Liu, Dongsheng, Chen, Rongjun, Zhou, Dejian
Format: Article
Language:English
Subjects:
DNA
drug delivery
nanomedicine
nanoparticles
pH-responsive
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Summary:A novel pH‐responsive DNA–gold nanoparticle conjugate that has high drug load, resists non‐specific serum protein adsorption and has high endocytotic cellular uptake is developed by Dejian Zhou, Rongjun Chen, and co‐workers on page 275. Upon acidification in intracellular endosomes/lysosomes, the formation of intramolecular i‐motif by the pH‐responsive DNA leads to efficient, pH‐triggered release of the anticancer drugs inside cancer cells, and hence high cytotoxicity.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201370008