Differential Susceptibility of Heart, Skin, and Islet Allografts to T Cell-Mediated Rejection

Although it is widely accepted that there is a hierarchy in the susceptibility of different allografts to rejection, the mechanisms responsible are unknown. We show that the increased susceptibility of H-2K(b+) skin and islet allografts to rejection is not based on their ability to activate more H-2...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2001-02, Vol.166 (4), p.2824-2830
Main Authors: Jones, Nick D, Turvey, Stuart E, Van Maurik, Andre, Hara, Masaki, Kingsley, Cherry I, Smith, Clare H, Mellor, Andrew L, Morris, Peter J, Wood, Kathryn J
Format: Article
Language:English
Subjects:
Animals
Cell Movement - immunology
Disease Susceptibility
Epitopes, T-Lymphocyte - biosynthesis
Graft Rejection - immunology
Graft Rejection - pathology
H-2 Antigens - biosynthesis
Heart Transplantation - immunology
Immune Tolerance
Immunologic Memory
Islets of Langerhans Transplantation - immunology
Isoantigens - immunology
Lymph Nodes - immunology
Lymph Nodes - pathology
Lymphocyte Activation
Lymphocyte Count
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Transgenic
Organ Transplantation
Postoperative Period
Skin Transplantation - immunology
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - pathology
T-Lymphocytes, Cytotoxic - immunology
Transplantation, Homologous
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Summary:Although it is widely accepted that there is a hierarchy in the susceptibility of different allografts to rejection, the mechanisms responsible are unknown. We show that the increased susceptibility of H-2K(b+) skin and islet allografts to rejection is not based on their ability to activate more H-2K(b)-specific T cells in vivo; heart allografts stimulate the activation and proliferation of many more H-2K(b)-specific T cells than either skin or islet allografts. Rejection of all three types of graft generate memory cells by 25 days posttransplant. These data provide evidence that neither tissue-specific Ags nor, surprisingly, the number of APCs carried in the graft dictate their susceptibility to T cell-mediated rejection and suggest that the graft microenvironment and size may play a more important role in determining the susceptibility of an allograft to rejection and resistance to tolerance induction.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.166.4.2824