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Vitamin D status in rheumatoid arthritis patients: relation to clinical manifestations, disease activity, quality of life and fibromyalgia syndrome
Aim To assess vitamin D levels in rheumatoid arthritis (RA) patients and to find their relation to clinical parameters, fibromyalgia syndrome (FMS), quality of life (QoL) and disease activity. Methods The study included 63 RA patients and 62 controls. Clinical examination and laboratory investigatio...
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| Published in: | International journal of rheumatic diseases 2016-03, Vol.19 (3), p.294-299 |
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| cites | cdi_FETCH-LOGICAL-c4096-2a44acf6a650f6d214af695d1b51db25f92a2cf19810813110fd1eb9584ddab93 |
| container_end_page | 299 |
| container_issue | 3 |
| container_start_page | 294 |
| container_title | International journal of rheumatic diseases |
| container_volume | 19 |
| creator | Gheita, Tamer A. Sayed, Safaa Gheita, Heba A. Kenawy, Sanaa A. |
| description | Aim
To assess vitamin D levels in rheumatoid arthritis (RA) patients and to find their relation to clinical parameters, fibromyalgia syndrome (FMS), quality of life (QoL) and disease activity.
Methods
The study included 63 RA patients and 62 controls. Clinical examination and laboratory investigations were performed. For patients, the Disease Activity Score (DAS‐28), QoL index, Health Assessment Questionnaire II (HAQ II) and Modified Larsen score were calculated. 25‐OH‐vitamin D was measured in patients and controls.
Results
The patients’ mean age was 41.59 ± 9.69 years and disease duration 5.89 ± 3.67 years. The level of vitamin D in RA patients was significantly lower (23.11 ± 12.71 ng/mL) than that in the controls (32.59 ± 13.06 ng/mL) (P = 0.005) being deficient in 50.8%, insufficient in 23.8% and normal in 25.4%. The RA patients with FMS (n = 33) had significantly lower levels of vitamin D (19.08 ± 10.59 ng/mL) than those without (27.55 ± 13.51 ng/mL) (P = 0.008). The difference was significant on comparing those receiving hydroxychloroquine (17.39 ± 7.84 ng/mL) to those not (31.85 ± 13.85 ng/mL) (P |
| doi_str_mv | 10.1111/1756-185X.12426 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1777076186</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4000556781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4096-2a44acf6a650f6d214af695d1b51db25f92a2cf19810813110fd1eb9584ddab93</originalsourceid><addsrcrecordid>eNqFkUtv1DAUhSMEoqWwZocssWHRtLlO7CTsSh9TpBGwKI-ddRPb1MVxprZDye_gD-Mw7SzY4I3Ptb9zdKWTZS-hOIJ0jqFmPIeGfTsCWlH-KNvfvTze6Qr2smch3BQFh5LXT7M9ymi7GPaz319MxME4ckZCxDgFkrS_VtOAcTSSoI_X3kQTyAajUS6Gt8Qrm_ToSBxJb40zPVoyoDNaLRnpJxwSaYLCoAj20fw0cT4ktxPaJMioiU0oQSeJNp0fhxntd4MkzE6mST3Pnmi0Qb24vw-yzxfnV6eX-frj6v3pyTrvq6LlOcWqwl5z5KzQXFKoUPOWSegYyI4y3VKkvYa2gaKBEqDQElTXsqaSEru2PMjebHM3fryd0u5iMKFX1qJT4xQE1HVd1BwantDX_6A34-Rd2m6hOEBFG5qo4y3V-zEEr7TYeDOgnwUUYulLLI2IpR3xt6_keHWfO3WDkjv-oaAEsC1wZ6ya_5cnTj6tH4Lzrc-EqH7tfOh_CF6XNRNfP6zEGby7aterS3FR_gHiBrFT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1776114282</pqid></control><display><type>article</type><title>Vitamin D status in rheumatoid arthritis patients: relation to clinical manifestations, disease activity, quality of life and fibromyalgia syndrome</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Gheita, Tamer A. ; Sayed, Safaa ; Gheita, Heba A. ; Kenawy, Sanaa A.</creator><creatorcontrib>Gheita, Tamer A. ; Sayed, Safaa ; Gheita, Heba A. ; Kenawy, Sanaa A.</creatorcontrib><description>Aim
To assess vitamin D levels in rheumatoid arthritis (RA) patients and to find their relation to clinical parameters, fibromyalgia syndrome (FMS), quality of life (QoL) and disease activity.
Methods
The study included 63 RA patients and 62 controls. Clinical examination and laboratory investigations were performed. For patients, the Disease Activity Score (DAS‐28), QoL index, Health Assessment Questionnaire II (HAQ II) and Modified Larsen score were calculated. 25‐OH‐vitamin D was measured in patients and controls.
Results
The patients’ mean age was 41.59 ± 9.69 years and disease duration 5.89 ± 3.67 years. The level of vitamin D in RA patients was significantly lower (23.11 ± 12.71 ng/mL) than that in the controls (32.59 ± 13.06 ng/mL) (P = 0.005) being deficient in 50.8%, insufficient in 23.8% and normal in 25.4%. The RA patients with FMS (n = 33) had significantly lower levels of vitamin D (19.08 ± 10.59 ng/mL) than those without (27.55 ± 13.51 ng/mL) (P = 0.008). The difference was significant on comparing those receiving hydroxychloroquine (17.39 ± 7.84 ng/mL) to those not (31.85 ± 13.85 ng/mL) (P < 0.001). Vitamin D significantly correlated with QoL index (r = 0.58, P < 0.001) and negatively with HAQ II (r = −0.36, P = 0.004) and BMI (r = −0.39, P = 0.001).
Conclusion
Special attention is required regarding vitamin D levels in RA patients with FMS and decreased QoL. Vitamin D should be corrected and supplementation considered among the RA management armamentarium.</description><identifier>ISSN: 1756-1841</identifier><identifier>EISSN: 1756-185X</identifier><identifier>DOI: 10.1111/1756-185X.12426</identifier><identifier>PMID: 25291242</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - diagnosis ; Arthritis, Rheumatoid - physiopathology ; Arthritis, Rheumatoid - psychology ; Biomarkers - blood ; Case-Control Studies ; Cost of Illness ; disease activity (DAS-28) ; Female ; Fibromyalgia - diagnosis ; Fibromyalgia - etiology ; Fibromyalgia - physiopathology ; Fibromyalgia - psychology ; fibromyalgia syndrome ; HAQ II ; Health Status ; Humans ; Male ; Middle Aged ; QoL ; Quality of Life ; rheumatoid arthritis ; Risk Factors ; Severity of Illness Index ; Surveys and Questionnaires ; vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - diagnosis</subject><ispartof>International journal of rheumatic diseases, 2016-03, Vol.19 (3), p.294-299</ispartof><rights>2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd</rights><rights>2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.</rights><rights>International Journal of Rheumatic Diseases © 2016 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4096-2a44acf6a650f6d214af695d1b51db25f92a2cf19810813110fd1eb9584ddab93</citedby><cites>FETCH-LOGICAL-c4096-2a44acf6a650f6d214af695d1b51db25f92a2cf19810813110fd1eb9584ddab93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25291242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gheita, Tamer A.</creatorcontrib><creatorcontrib>Sayed, Safaa</creatorcontrib><creatorcontrib>Gheita, Heba A.</creatorcontrib><creatorcontrib>Kenawy, Sanaa A.</creatorcontrib><title>Vitamin D status in rheumatoid arthritis patients: relation to clinical manifestations, disease activity, quality of life and fibromyalgia syndrome</title><title>International journal of rheumatic diseases</title><addtitle>Int J Rheum Dis</addtitle><description>Aim
To assess vitamin D levels in rheumatoid arthritis (RA) patients and to find their relation to clinical parameters, fibromyalgia syndrome (FMS), quality of life (QoL) and disease activity.
Methods
The study included 63 RA patients and 62 controls. Clinical examination and laboratory investigations were performed. For patients, the Disease Activity Score (DAS‐28), QoL index, Health Assessment Questionnaire II (HAQ II) and Modified Larsen score were calculated. 25‐OH‐vitamin D was measured in patients and controls.
Results
The patients’ mean age was 41.59 ± 9.69 years and disease duration 5.89 ± 3.67 years. The level of vitamin D in RA patients was significantly lower (23.11 ± 12.71 ng/mL) than that in the controls (32.59 ± 13.06 ng/mL) (P = 0.005) being deficient in 50.8%, insufficient in 23.8% and normal in 25.4%. The RA patients with FMS (n = 33) had significantly lower levels of vitamin D (19.08 ± 10.59 ng/mL) than those without (27.55 ± 13.51 ng/mL) (P = 0.008). The difference was significant on comparing those receiving hydroxychloroquine (17.39 ± 7.84 ng/mL) to those not (31.85 ± 13.85 ng/mL) (P < 0.001). Vitamin D significantly correlated with QoL index (r = 0.58, P < 0.001) and negatively with HAQ II (r = −0.36, P = 0.004) and BMI (r = −0.39, P = 0.001).
Conclusion
Special attention is required regarding vitamin D levels in RA patients with FMS and decreased QoL. Vitamin D should be corrected and supplementation considered among the RA management armamentarium.</description><subject>Adult</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - diagnosis</subject><subject>Arthritis, Rheumatoid - physiopathology</subject><subject>Arthritis, Rheumatoid - psychology</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Cost of Illness</subject><subject>disease activity (DAS-28)</subject><subject>Female</subject><subject>Fibromyalgia - diagnosis</subject><subject>Fibromyalgia - etiology</subject><subject>Fibromyalgia - physiopathology</subject><subject>Fibromyalgia - psychology</subject><subject>fibromyalgia syndrome</subject><subject>HAQ II</subject><subject>Health Status</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>QoL</subject><subject>Quality of Life</subject><subject>rheumatoid arthritis</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Surveys and Questionnaires</subject><subject>vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin D Deficiency - diagnosis</subject><issn>1756-1841</issn><issn>1756-185X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkUtv1DAUhSMEoqWwZocssWHRtLlO7CTsSh9TpBGwKI-ddRPb1MVxprZDye_gD-Mw7SzY4I3Ptb9zdKWTZS-hOIJ0jqFmPIeGfTsCWlH-KNvfvTze6Qr2smch3BQFh5LXT7M9ymi7GPaz319MxME4ckZCxDgFkrS_VtOAcTSSoI_X3kQTyAajUS6Gt8Qrm_ToSBxJb40zPVoyoDNaLRnpJxwSaYLCoAj20fw0cT4ktxPaJMioiU0oQSeJNp0fhxntd4MkzE6mST3Pnmi0Qb24vw-yzxfnV6eX-frj6v3pyTrvq6LlOcWqwl5z5KzQXFKoUPOWSegYyI4y3VKkvYa2gaKBEqDQElTXsqaSEru2PMjebHM3fryd0u5iMKFX1qJT4xQE1HVd1BwantDX_6A34-Rd2m6hOEBFG5qo4y3V-zEEr7TYeDOgnwUUYulLLI2IpR3xt6_keHWfO3WDkjv-oaAEsC1wZ6ya_5cnTj6tH4Lzrc-EqH7tfOh_CF6XNRNfP6zEGby7aterS3FR_gHiBrFT</recordid><startdate>201603</startdate><enddate>201603</enddate><creator>Gheita, Tamer A.</creator><creator>Sayed, Safaa</creator><creator>Gheita, Heba A.</creator><creator>Kenawy, Sanaa A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201603</creationdate><title>Vitamin D status in rheumatoid arthritis patients: relation to clinical manifestations, disease activity, quality of life and fibromyalgia syndrome</title><author>Gheita, Tamer A. ; Sayed, Safaa ; Gheita, Heba A. ; Kenawy, Sanaa A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4096-2a44acf6a650f6d214af695d1b51db25f92a2cf19810813110fd1eb9584ddab93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - diagnosis</topic><topic>Arthritis, Rheumatoid - physiopathology</topic><topic>Arthritis, Rheumatoid - psychology</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Cost of Illness</topic><topic>disease activity (DAS-28)</topic><topic>Female</topic><topic>Fibromyalgia - diagnosis</topic><topic>Fibromyalgia - etiology</topic><topic>Fibromyalgia - physiopathology</topic><topic>Fibromyalgia - psychology</topic><topic>fibromyalgia syndrome</topic><topic>HAQ II</topic><topic>Health Status</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>QoL</topic><topic>Quality of Life</topic><topic>rheumatoid arthritis</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Surveys and Questionnaires</topic><topic>vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin D Deficiency - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gheita, Tamer A.</creatorcontrib><creatorcontrib>Sayed, Safaa</creatorcontrib><creatorcontrib>Gheita, Heba A.</creatorcontrib><creatorcontrib>Kenawy, Sanaa A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gheita, Tamer A.</au><au>Sayed, Safaa</au><au>Gheita, Heba A.</au><au>Kenawy, Sanaa A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D status in rheumatoid arthritis patients: relation to clinical manifestations, disease activity, quality of life and fibromyalgia syndrome</atitle><jtitle>International journal of rheumatic diseases</jtitle><addtitle>Int J Rheum Dis</addtitle><date>2016-03</date><risdate>2016</risdate><volume>19</volume><issue>3</issue><spage>294</spage><epage>299</epage><pages>294-299</pages><issn>1756-1841</issn><eissn>1756-185X</eissn><abstract>Aim
To assess vitamin D levels in rheumatoid arthritis (RA) patients and to find their relation to clinical parameters, fibromyalgia syndrome (FMS), quality of life (QoL) and disease activity.
Methods
The study included 63 RA patients and 62 controls. Clinical examination and laboratory investigations were performed. For patients, the Disease Activity Score (DAS‐28), QoL index, Health Assessment Questionnaire II (HAQ II) and Modified Larsen score were calculated. 25‐OH‐vitamin D was measured in patients and controls.
Results
The patients’ mean age was 41.59 ± 9.69 years and disease duration 5.89 ± 3.67 years. The level of vitamin D in RA patients was significantly lower (23.11 ± 12.71 ng/mL) than that in the controls (32.59 ± 13.06 ng/mL) (P = 0.005) being deficient in 50.8%, insufficient in 23.8% and normal in 25.4%. The RA patients with FMS (n = 33) had significantly lower levels of vitamin D (19.08 ± 10.59 ng/mL) than those without (27.55 ± 13.51 ng/mL) (P = 0.008). The difference was significant on comparing those receiving hydroxychloroquine (17.39 ± 7.84 ng/mL) to those not (31.85 ± 13.85 ng/mL) (P < 0.001). Vitamin D significantly correlated with QoL index (r = 0.58, P < 0.001) and negatively with HAQ II (r = −0.36, P = 0.004) and BMI (r = −0.39, P = 0.001).
Conclusion
Special attention is required regarding vitamin D levels in RA patients with FMS and decreased QoL. Vitamin D should be corrected and supplementation considered among the RA management armamentarium.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25291242</pmid><doi>10.1111/1756-185X.12426</doi><tpages>6</tpages></addata></record> |
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| ispartof | International journal of rheumatic diseases, 2016-03, Vol.19 (3), p.294-299 |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - diagnosis Arthritis, Rheumatoid - physiopathology Arthritis, Rheumatoid - psychology Biomarkers - blood Case-Control Studies Cost of Illness disease activity (DAS-28) Female Fibromyalgia - diagnosis Fibromyalgia - etiology Fibromyalgia - physiopathology Fibromyalgia - psychology fibromyalgia syndrome HAQ II Health Status Humans Male Middle Aged QoL Quality of Life rheumatoid arthritis Risk Factors Severity of Illness Index Surveys and Questionnaires vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - complications Vitamin D Deficiency - diagnosis |
| title | Vitamin D status in rheumatoid arthritis patients: relation to clinical manifestations, disease activity, quality of life and fibromyalgia syndrome |
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