Peripheral markers of oxidative stress and antioxidative defense in euthymia of bipolar disorder—Gender and obesity effects

Abstract Introduction Oxidative and nitrosative stress are implicated in the pathogenesis of uni- and bipolar disorder. Herein we primarily sought to characterize markers of oxidative/nitrosative stress during euthymia in adults with bipolar disorder (BD). Oxidative markers were further evaluated in...

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Bibliographic Details
Published in:Journal of affective disorders 2015-02, Vol.172, p.367-374
Main Authors: Bengesser, S.A, Lackner, N, Birner, A, Fellendorf, F.T, Platzer, M, Mitteregger, A, Unterweger, R, Reininghaus, B, Mangge, H, Wallner-Liebmann, S.J, Zelzer, S, Fuchs, D, McIntyre, R.S, Kapfhammer, H.P, Reininghaus, E.Z
Format: Article
Language:English
Subjects:
Adult
Antioxidants
Antioxidants - metabolism
Biomarkers - blood
Bipolar disorder
Bipolar Disorder - blood
Bipolar Disorder - metabolism
Body Mass Index
Cyclothymic Disorder - blood
Cyclothymic Disorder - metabolism
Female
Glutathione S-transferase
Glutathione Transferase - blood
Humans
Male
Malondialdehyde
Malondialdehyde - blood
Metabolic Syndrome - blood
Middle Aged
Obesity - blood
Obesity - metabolism
Overweight - blood
Oxidative Stress
Psychiatry
Sex Factors
Superoxide Dismutase - blood
Thiobarbituric Acid Reactive Substances - metabolism
Total antioxidative capacity
Waist-Hip Ratio
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Summary:Abstract Introduction Oxidative and nitrosative stress are implicated in the pathogenesis of uni- and bipolar disorder. Herein we primarily sought to characterize markers of oxidative/nitrosative stress during euthymia in adults with bipolar disorder (BD). Oxidative markers were further evaluated in this BD sample in synopsis with excess overweight or obesity and/or comorbid metabolic syndrome (MetS). Methods Peripheral markers of oxidative stress [i.e. thiobarbituric acid reactive substance, (TBARS), malondialdehyde (MDA), and carbonyl proteins] and antioxidant markers [e.g. total antioxidative capacity (TAC), superoxide dismutase (SOD), glutathione S -transferase (GST)] were obtained in a cohort of euthymic adults with BD ( N =113) and compared to healthy controls (CG) ( N =78). Additionally, anthropometric measures included the body mass index (BMI) [kg/m2 ], waist and hip circumference [cm], waist-to-hip-ratio (WHR), waist to height ratio (WtHR) as well as the IDF-defined MetS. Results The major finding was a significantly decreased TAC in BD compared to the CG ( p
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2014.10.014