Developing fibre optic Raman probes for applications in clinical spectroscopy

Raman spectroscopy has been shown by various groups over the last two decades to have significant capability in discriminating disease states in bodily fluids, cells and tissues. Recent development in instrumentation, optics and manufacturing approaches has facilitated the design and demonstration o...

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Bibliographic Details
Published in:Chemical Society reviews 2016-04, Vol.45 (7), p.1919-1934
Main Authors: Stevens, Oliver, Iping Petterson, Ingeborg E, Day, John C. C, Stone, Nick
Format: Article
Language:English
Subjects:
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Clinical Laboratory Techniques - instrumentation
Clinical Laboratory Techniques - methods
Design analysis
Fiber Optic Technology - instrumentation
Fiber optics
Fluid dynamics
Humans
Instrumentation
Optical fibers
Raman spectroscopy
Spectra
Spectrum Analysis, Raman - instrumentation
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Summary:Raman spectroscopy has been shown by various groups over the last two decades to have significant capability in discriminating disease states in bodily fluids, cells and tissues. Recent development in instrumentation, optics and manufacturing approaches has facilitated the design and demonstration of various novel in vivo probes, which have applicability for myriad of applications. This review focusses on key considerations and recommendations for application specific clinical Raman probe design and construction. Raman probes can be utilised as clinical tools able to provide rapid, non-invasive, real-time molecular analysis of disease specific changes in tissues. Clearly the target tissue location, the significance of spectral changes with disease and the possible access routes to the region of interest will vary for each clinical application considered. This review provides insight into design and construction considerations, including suitable probe designs and manufacturing materials compatible with Raman spectroscopy. Raman spectroscopy has been shown by various groups over the last two decades to have significant capability in discriminating disease states in bodily fluids, cells and tissues.
ISSN:0306-0012
1460-4744
DOI:10.1039/c5cs00850f