The permuted locus trial— Well suited for emerging pathogens?

Abstract The recent Ebola virus epidemic was waning by the time stakeholders were ready to field vaccines for testing but an evidence-based response to a novel pathogen will surely be required again. Here, we present a design for such a randomized controlled trial. The permuted locus trial was origi...

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Bibliographic Details
Published in:Contemporary clinical trials 2016-03, Vol.47, p.72-73
Main Authors: Porco, Travis C, Keenan, Jeremy D, Enanoria, Wayne T.A, Lietman, Thomas M
Format: Article
Language:English
Subjects:
Cardiovascular
Cluster randomized controlled trial
Ebola
Ebola Vaccines - therapeutic use
Hematology, Oncology and Palliative Medicine
Hemorrhagic Fever, Ebola - prevention & control
Humans
Permuted locus trial
Research Design
Trachoma
Trachoma - prevention & control
Water Wells
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Summary:Abstract The recent Ebola virus epidemic was waning by the time stakeholders were ready to field vaccines for testing but an evidence-based response to a novel pathogen will surely be required again. Here, we present a design for such a randomized controlled trial. The permuted locus trial was originally intended for studying the influence of water wells on trachoma. While outcomes can be measured in individuals, neither individuals nor groups are themselves randomized to arms, just potential well-sites, or in the case of an epidemic, index cases. The permuted locus trial may be used when classic individual and cluster-randomized trial design and analyses may not be optimal.
ISSN:1551-7144
1559-2030
DOI:10.1016/j.cct.2015.12.008