Whey protein isolate decreases murine stomach weight and intestinal length and alters the expression of Wnt signalling-associated genes

The present study examined the underlying mechanisms by which whey protein isolate (WPI) affects energy balance. C57BL/6J mice were fed a diet containing 10 % energy from fat, 70 % energy from carbohydrate (35 % energy from sucrose) and 20 % energy from casein or WPI for 15 weeks. Mice fed with WPI...

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Bibliographic Details
Published in:British journal of nutrition 2015-01, Vol.113 (2), p.372-379
Main Authors: McAllan, Liam, Speakman, John R., Cryan, John F., Nilaweera, Kanishka N.
Format: Article
Language:English
Subjects:
Adiposity
Animals
Behaviour, Appetite and Obesity
Cattle
Diet
Diet, Fat-Restricted - economics
Digestive system
Duodenum - growth & development
Duodenum - metabolism
Duodenum - pathology
Energy balance
Energy Intake
Food-Processing Industry - economics
Gene expression
Gene Expression Regulation
Ileum - growth & development
Ileum - metabolism
Ileum - pathology
Industrial Waste - analysis
Industrial Waste - economics
Ireland
Male
Mice, Inbred C57BL
Organ Size
Organ Specificity
Overweight - blood
Overweight - metabolism
Overweight - pathology
Overweight - prevention & control
Oxygen Consumption
Proteins
Rodents
Stomach
Stomach - growth & development
Stomach - metabolism
Stomach - pathology
Time Factors
Weight
Weight Gain
Whey Proteins - economics
Whey Proteins - metabolism
Whey Proteins - therapeutic use
Wnt Signaling Pathway
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Summary:The present study examined the underlying mechanisms by which whey protein isolate (WPI) affects energy balance. C57BL/6J mice were fed a diet containing 10 % energy from fat, 70 % energy from carbohydrate (35 % energy from sucrose) and 20 % energy from casein or WPI for 15 weeks. Mice fed with WPI had reduced weight gain, cumulative energy intake and dark-phase VO2 compared with casein-fed mice (P
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114514004024