Potential of neuropeptide Y for preventing or treating post-traumatic stress disorder

Abstract There is extensive evidence that NPY in the brain can modulate the responses to stress and play a critical role in resistance to, or recovery from, harmful effects of stress. Development of PTSD and comorbid depression following exposure to traumatic stress are associated with low NPY. This...

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Bibliographic Details
Published in:Neuropeptides (Edinburgh) 2016-04, Vol.56, p.19-24
Main Authors: Sabban, Esther L, Alaluf, Lishay G, Serova, Lidia I
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Brain - drug effects
Brain - metabolism
Depression
Endocrinology & Metabolism
Humans
Intranasal
Neuropeptide Y - administration & dosage
Neuropeptide Y - metabolism
PTSD
Resilience
Single prolonged stress
Stress Disorders, Post-Traumatic - metabolism
Stress Disorders, Post-Traumatic - prevention & control
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Summary:Abstract There is extensive evidence that NPY in the brain can modulate the responses to stress and play a critical role in resistance to, or recovery from, harmful effects of stress. Development of PTSD and comorbid depression following exposure to traumatic stress are associated with low NPY. This review discusses putative mechanisms for NPY's anti-stress actions. Recent preclinical data indicating potential for intranasal delivery of NPY to brain as a promising non-invasive strategy to prevent a variety of neuroendocrine, molecular and behavioral impairments in PTSD model are summarized.
ISSN:0143-4179
1532-2785
DOI:10.1016/j.npep.2015.11.004