Facile Preparation of Core-Shell Magnetic Metal-Organic Framework Nanospheres for the Selective Enrichment of Endogenous Peptides

Facile preparation of core–shell magnetic metal–organic framework nanospheres by a layer‐by‐layer approach is presented. The nanospheres have high surface area (285.89 cm2 g−1), large pore volume (0.18 cm3 g−1), two kinds of mesopores (2.50 and 4.72 nm), excellent magnetic responsivity (55.65 emu g−...

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Bibliographic Details
Published in:Chemistry : a European journal 2014-06, Vol.20 (24), p.7389-7395
Main Authors: Xiong , Zhichao, Ji , Yongsheng, Fang, Chunli, Zhang, Quanqing, Zhang, Lingyi, Ye, Mingliang, Zhang , Weibing, Zou, Hanfa
Format: Article
Language:English
Subjects:
Chemistry
core-shell structures
Enrichment
Human
Hydrophobicity
Magnetic Phenomena
magnetic properties
Metal-organic frameworks
Metalorganic compounds
Nanoparticles
Nanospheres
Peptides
Peptides - chemistry
Physical Phenomena
Porosity
Serums
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Summary:Facile preparation of core–shell magnetic metal–organic framework nanospheres by a layer‐by‐layer approach is presented. The nanospheres have high surface area (285.89 cm2 g−1), large pore volume (0.18 cm3 g−1), two kinds of mesopores (2.50 and 4.72 nm), excellent magnetic responsivity (55.65 emu g−1), structural stability, and good dispersibility. The combination of porosity, hydrophobicity, and uniform magnetism was exploited for effective enrichment of peptides with simultaneous exclusion of high molecular weight proteins. The nanospheres were successfully applied in the selective enrichment of endogenous peptides in human serum. Selective enrichment and quick separation: Core–shell magnetic metal–organic framework nanospheres were fabricated by a layer‐by‐layer approach. This material, denoted Fe3O4@MIL‐100(Fe), was applied as a magnetic adsorbent for the selective enrichment of endogenous peptides from human serum (see scheme), and the method showed convenient operation and effective and selective extraction.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201400389