Chitosan-glycolipid nanogels loaded with anti-obese marine carotenoid fucoxanthin: Acute and sub-acute toxicity evaluation in rodent model

Fucoxanthin (FUCO) is a light- and heat-sensitive marine xanthophyll carotenoid, present in brown algae that render physiological properties as anti-oxidants. In this study, nanoencapsulation is an approach adopted to improve bioavailability of FUCO by using ionic-gelation method with polymeric chit...

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Bibliographic Details
Published in:Journal of biomaterials applications 2015-10, Vol.30 (4), p.420-434
Main Authors: Ravi, Hindupur, Arunkumar, Ranganathan, Baskaran, Vallikannan
Format: Article
Language:English
Subjects:
Algae
Animals
Anti-Obesity Agents - administration & dosage
Anti-Obesity Agents - chemistry
Anti-Obesity Agents - toxicity
Biocompatibility
Carotenoids
Chitosan
Chitosan - chemistry
Drug Carriers - chemistry
Female
Gels - chemistry
Glycolipids - chemistry
Marine
Nanostructure
Rats
Rats, Wistar
Seaweed - chemistry
Toxicity
Xanthophylls - administration & dosage
Xanthophylls - chemistry
Xanthophylls - toxicity
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Summary:Fucoxanthin (FUCO) is a light- and heat-sensitive marine xanthophyll carotenoid, present in brown algae that render physiological properties as anti-oxidants. In this study, nanoencapsulation is an approach adopted to improve bioavailability of FUCO by using ionic-gelation method with polymeric chitosan (CS) dispersed in glycolipid (GL), as a carrier. Further, the aim was to investigate adverse effect of acute and sub-acute toxicity of chitosan nanogels (CS-NGs) loaded with FUCO+GL in rats. In the acute toxicity study, FUCO was fed to rats at doses of 0.1, 1, 10 and 100 mg/kg body weight (BW). In the sub-acute toxicity study, FUCO was fed at doses of 1 and 10 mg/kg BW for 28 days. In both the studies, no mortality and abnormalities in gross morphology were observed. Acute toxicity study revealed that the LD50 of FUCO in CS-NGs is higher than 100 mg/kg BW. No postprandial plasma levels of FUCO were detected. However, fucoxanthinol (FUOH), a hydrolytic metabolite of FUCO was detected in a dose dependent manner (P 
ISSN:0885-3282
1530-8022
DOI:10.1177/0885328215590753