Acetylcholine-Triggered Cargo Release from Supramolecular Nanovalves Based on Different Macrocyclic Receptors

Acetylcholine (ACh), a neurotransmitter located in cholinergic synapses, can trigger cargo release from mesoporous silica nanoparticles equipped with calixarene‐ or pillarene‐based nanovalves by removing macrocycles from the stalk components. The amount and speed of cargo release can be controlled b...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry : a European journal 2014-03, Vol.20 (11), p.2998-3004
Main Authors: Zhou, Yue, Tan, Li-Li, Li, Qing-Lan, Qiu, Xi-Long, Qi, Ai-Di, Tao, Yanchun, Yang, Ying-Wei
Format: Article
Language:English
Subjects:
acetylcholine
Acetylcholine - chemistry
Acetylcholine - pharmacology
Biocompatible Materials - chemistry
Calixarenes - chemistry
Cargo
Central nervous system
Central Nervous System - chemistry
Central Nervous System - drug effects
Chemistry
drug delivery
Gating and risering
macrocyclic chemistry
Macrocyclic compounds
Macrocyclic Compounds - chemistry
Medical services
mesoporous materials
Nanoparticles
Nanoparticles - chemistry
Nanostructure
Neurotransmitters
Silica
silica nanoparticles
Silicon dioxide
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acetylcholine (ACh), a neurotransmitter located in cholinergic synapses, can trigger cargo release from mesoporous silica nanoparticles equipped with calixarene‐ or pillarene‐based nanovalves by removing macrocycles from the stalk components. The amount and speed of cargo release can be controlled by varying the concentration of ACh in solution or changing the type of gating macrocycle. Although this proof‐of‐concept study is far from a real‐life application, it provides a possible route to treat diseases related to the central nervous system. Supramolecular nanovalves: Mesoporous silica nanoparticles (MSNs) equipped with calixarene‐ or pillarene‐based nanovalves were prepared and characterized (see scheme). Acetylcholine (ACh), a neurotransmitter, successfully triggered cargo release from the nanocontainers, which could be useful for Parkinson's disease (PD) treatment.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201304864