Fast and Efficient super(18)F-Labeling by [ super(18)F]Fluorophenylazocarboxylic Esters

Introduction of [ super(18)F]fluoride ion into the aromatic core of phenylazocarboxylic esters was achieved in only 30seconds, with radiochemical yields of up to 95% (85( plus or minus 10)%). For labeling purposes, the resulting super(18)F-substituted azoester can be further converted in radical-ary...

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Bibliographic Details
Published in:Chemistry : a European journal 2014-01, Vol.20 (2), p.370-375
Main Authors: Fehler, Stefanie K, Maschauer, Simone, Hofling, Sarah B, Bartuschat, Amelie L, Tschammer, Nuska, Huebner, Harald, Gmeiner, Peter, Prante, Olaf, Heinrich, Markus R
Format: Article
Language:English
Subjects:
Carbonyls
Esters
Marking
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Summary:Introduction of [ super(18)F]fluoride ion into the aromatic core of phenylazocarboxylic esters was achieved in only 30seconds, with radiochemical yields of up to 95% (85( plus or minus 10)%). For labeling purposes, the resulting super(18)F-substituted azoester can be further converted in radical-arylation reactions to give biaryls, or in substitutions at its carbonyl unit to produce azocarboxamides. Aromatic substitution: Introduction of [ super(18)F]fluoride ion into the aromatic core of phenylazocarboxylic esters was achieved in only 30seconds, and with radiochemical yields up to 95% (85( plus or minus 10)%). For labeling purposes, the resulting super(18)F-substituted azoester can be further converted in radical-arylation reactions to give biaryls, or in substitutions at its carbonyl unit to produce azocarboxamides (see scheme).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201303409