Highly Enantioselective Intermolecular Hydroamination of Allylic Amines with Chiral Aldehydes as Tethering Catalysts

Chirally LinkedIn: Chiral aldehydes are effective tethering catalysts for enantioselective intermolecular hydroamination, which provides access to vicinal diamine motifs in good yields and excellent enantioselectivities (see scheme). This work highlights simple chiral α‐oxygenated aldehydes as effec...

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Published in:Chemistry : a European journal 2013-02, Vol.19 (8), p.2597-2601
Main Authors: MacDonald, Melissa J., Hesp, Colin R., Schipper, Derek J., Pesant, Marc, Beauchemin, André M.
Format: Article
Language:English
Subjects:
Aldehydes
Aldehydes - chemistry
Alkenes - chemistry
Amination
Amines
Amines - chemistry
asymmetric catalysis
Asymmetry
Catalysis
Catalysts
Chemistry
Diamines
hydroamination
hydroxylamines
Stereoisomerism
tethered reactions
Tethering
vicinal diamines
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cited_by cdi_FETCH-LOGICAL-c4812-9f518059bfb4dc0adbe47c60f1e7978617832499bc43a4778bb1fed0cdb1672b3
cites cdi_FETCH-LOGICAL-c4812-9f518059bfb4dc0adbe47c60f1e7978617832499bc43a4778bb1fed0cdb1672b3
container_end_page 2601
container_issue 8
container_start_page 2597
container_title Chemistry : a European journal
container_volume 19
creator MacDonald, Melissa J.
Hesp, Colin R.
Schipper, Derek J.
Pesant, Marc
Beauchemin, André M.
description Chirally LinkedIn: Chiral aldehydes are effective tethering catalysts for enantioselective intermolecular hydroamination, which provides access to vicinal diamine motifs in good yields and excellent enantioselectivities (see scheme). This work highlights simple chiral α‐oxygenated aldehydes as effective organocatalysts capable of efficiently inducing asymmetry through transient intramolecularity.
doi_str_mv 10.1002/chem.201203462
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ispartof Chemistry : a European journal, 2013-02, Vol.19 (8), p.2597-2601
issn 0947-6539
1521-3765
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subjects Aldehydes
Aldehydes - chemistry
Alkenes - chemistry
Amination
Amines
Amines - chemistry
asymmetric catalysis
Asymmetry
Catalysis
Catalysts
Chemistry
Diamines
hydroamination
hydroxylamines
Stereoisomerism
tethered reactions
Tethering
vicinal diamines
title Highly Enantioselective Intermolecular Hydroamination of Allylic Amines with Chiral Aldehydes as Tethering Catalysts
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