Association between whole blood mercury and glucose intolerance among adult Inuit in Greenland

The Arctic diet is partly constituted by traditional food characterized by top predator animals such as whales, walrus, and seals with high mercury content. Mercury exposure has been associated with glucose intolerance in Western populations. We studied the association between whole blood mercury an...

Full description

Saved in:
Bibliographic Details
Published in:Environmental research 2015-11, Vol.143 (Pt A), p.192-197
Main Authors: Jeppesen, Charlotte, Valera, Beatriz, Nielsen, Nina O., Bjerregaard, Peter, Jørgensen, Marit E.
Format: Article
Language:English
Subjects:
Adult
Blood
Blood Glucose - analysis
Cetacea
Cross-Sectional Studies
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - etiology
Diet
Energy Intake
Environmental Exposure - analysis
Fasting
Glucose
Glucose intolerance
Glucose Intolerance - blood
Glucose Intolerance - epidemiology
Glucose Intolerance - etiology
Glucose Tolerance Test
Greenland - epidemiology
Humans
Insulin
Inuit
Inuits - statistics & numerical data
Logistic Models
Mathematical models
Mercury (metal)
Mercury - blood
Middle Aged
Motor Activity
Populations
Surveys and Questionnaires
Tolerances
Type 2 diabetes
Water Pollutants, Chemical - blood
Whole blood mercury
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Arctic diet is partly constituted by traditional food characterized by top predator animals such as whales, walrus, and seals with high mercury content. Mercury exposure has been associated with glucose intolerance in Western populations. We studied the association between whole blood mercury and glucose intolerance in a highly exposed non-Western population Cross-sectional study of 2640 Inuit (18+ years) with information on ancestry, smoking, waist circumference, total energy intake, and physical activity. Mercury, fasting- and 2-h plasma glucose, insulin, and c-peptide were measured in blood. Fasting participants without diabetes were classified into normal glucose tolerance, impaired glucose tolerance, impaired fasting glycemia, or type 2 diabetes. We calculated hepatic insulin resistance with homoeostatic model assessment – insulin resistance index, peripheral insulin sensitivity by ISI0,120., and relative beta cell function by c-peptide/insulin ratio. We conducted adjusted linear- and logistic regression analyses. For an increase in whole blood mercury of 5µg/L we found a positive association with fasting glucose [% change=0.25 (95% CI: 0.20; 0.30); p
ISSN:0013-9351
1096-0953
DOI:10.1016/j.envres.2015.10.013