Salimabromide: Unexpected Chemistry from the Obligate Marine Myxobacterium Enhygromxyasalina

Marine myxobacteria (Enhygromyxa, Plesiocystis, Pseudoenhygromyxa, Haliangium) are phylogenetically distant from their terrestrial counterparts. Salimabromide is the first natural product from the Plesiocystis/Enhygromyxa clade of obligatory marine myxobacteria. Salimabromide has a new tetracyclic c...

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Bibliographic Details
Published in:Chemistry : a European journal 2013-07, Vol.19 (28), p.9319-9324
Main Authors: Felder, Stephan, Dreisigacker, Sandra, Kehraus, Stefan, Neu, Edith, Bierbaum, Gabriele, Wright, Patrick R, Menche, Dirk, Schäberle, Till F, König, Gabriele M
Format: Article
Language:English
Subjects:
Bromination
Carbon
Chemistry
Cyclohexane
Dichroism
Lactones
Marine
Mathematical analysis
Residues
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Summary:Marine myxobacteria (Enhygromyxa, Plesiocystis, Pseudoenhygromyxa, Haliangium) are phylogenetically distant from their terrestrial counterparts. Salimabromide is the first natural product from the Plesiocystis/Enhygromyxa clade of obligatory marine myxobacteria. Salimabromide has a new tetracyclic carbon skeleton, comprising a brominated benzene ring, a furano lactone residue, and a cyclohexane ring, bridged by a seven-membered cyclic moiety. The absolute configuration was deduced from experimental and calculated CD data. Salimabromide revealed antibiotic activity towards Arthrobacter cristallopoietes. [PUBLICATION ABSTRACT]
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201301379