Prenatal nonylphenol exposure, oxidative and nitrative stress, and birth outcomes: A cohort study in Taiwan

• Published in: Environmental pollution (1987) 2015-12, Vol.207, p.145-151
• Main Authors: Wang, Pei-Wei, Chen, Mei-Lien, Huang, Li-Wei, Yang, Winnie, Wu, Kuen-Yuh, Huang, Yu-Fang
• Format: Article
• Language: English
• Subjects: Acetylcysteine - analogs & derivatives; Acetylcysteine - urine; Adult; Biomarkers; Biomarkers - urine; Birth; Birth outcomes; Birth Weight; Circumferences; Cohort Studies; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - urine; Dinoprost - analogs & derivatives; Dinoprost - urine; DNA Damage; Environmental Pollutants; Exposure; Female; Gestational Age; Guanine - analogs & derivatives; Guanine - urine; Humans; Infant, Newborn; Lipid Peroxidation; Lipids; Male; Maternal Exposure; Monitoring; Nonylphenol; Oxidative and nitrative DNA damage; Oxidative Stress; Phenols; Pollution abatement; Pregnancy; Pregnancy Outcome; Stresses; Taiwan - epidemiology
• ISSN: 0269-7491; 1873-6424
• DOI: 10.1016/j.envpol.2015.08.044

Data concerning the effects of prenatal exposures to nonylphenol (NP) and oxidative stress on neonatal birth outcomes from human studies are limited. A total of 146 pregnant women were studied (1) to investigate the association between prenatal NP exposure and maternal oxidative/nitrative stress biomarkers of DNA damage (8-hydroxy-2’-deoxyguanosine (8-OHdG), 8-nitroguanine (8-NO2Gua)) and lipid peroxidation (8-iso-prostaglandin F2α (8-isoPF2α), 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA)) and (2) to explore the associations among oxidative stress biomarkers, NP exposure, and neonatal birth outcomes, including gestational age, birth weight, length, Ponderal index, and head and chest circumferences. NP significantly increased the 8-OHdG and 8-NO2Gua levels. All infants born to mothers with urinary 8-OHdG levels above the median exhibited a significantly shorter gestational duration (Badjusted = −4.72 days; 95% CI: −8.08 to −1.36 days). No clear association was found between NP levels and birth outcomes. Prenatal 8-OHdG levels might be a novel biomarker for monitoring fetal health related to NP exposure. •A cohort of pregnant women was established and followed until delivery.•NP significantly increased 8-OHdG and 8-NO2Gua levels.•Maternal 8-OHdG levels were associated with significantly decreased gestational duration.•No clear association was observed between NP and birth outcomes. NP increased 8-OHdG and 8-NO2Gua levels; high 8-OHdG levels significantly decreased gestation length.