A Concise Synthesis of L-Pyrrolysine

Organocatalysis: A concise synthesis of L‐pyrrolysine has been accomplished in six steps from simple starting materials. The facile synthetic strategy relies on an organocatalytic Michael addition, an efficient amide coupling, and a challenging method for the imine‐bond construction (see scheme)....

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Bibliographic Details
Published in:Chemistry : a European journal 2013-06, Vol.19 (25), p.8078-8081
Main Authors: Han, Man-Yi, Wang, Huai-Zhen, An, Wan-Kai, Jia, Ju-Ying, Ma, Bao-Chun, Zhang, Yuan, Wang, Wei
Format: Article
Language:English
Subjects:
amide coupling
Amides
Amides - chemistry
asymmetric synthesis
Chemistry
Construction
Imines - chemistry
Joining
Lysine - analogs & derivatives
Lysine - chemical synthesis
Molecular Structure
one-pot synthesis
organocatalysis
pyrrolysine
Stereoisomerism
Strategy
Synthesis
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Summary:Organocatalysis: A concise synthesis of L‐pyrrolysine has been accomplished in six steps from simple starting materials. The facile synthetic strategy relies on an organocatalytic Michael addition, an efficient amide coupling, and a challenging method for the imine‐bond construction (see scheme).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201300403