Validation of QuEChERS-based method for determination of flusilazole residues in grape by high-performance liquid chromatography with photodiode array detector

A high-performance liquid chromatography with photodiode array detector analytical method was developed to determine the residue levels of flusilazole in grape and investigate the dissipation pattern and safety. The results showed that the mean recoveries were in the range of 86%-90%. Limits of dete...

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Bibliographic Details
Published in:Toxicological and environmental chemistry 2015-10, Vol.97 (9), p.1137-1144
Main Authors: Malhat, Farag, Loutfy, Naglaa M., Ahmed, Mohamed Tawfic
Format: Article
Language:English
Subjects:
Analytical chemistry
Arrays
Berries
Chromatography
Detectors
dissipation
Dosage
flusilazole
Food safety
Grapes
Health hazards
HPLC-DAD
Kinetics
Liquid chromatography
Mathematical analysis
Pesticides
Photodiodes
Residues
risk assessment
Vitaceae
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Summary:A high-performance liquid chromatography with photodiode array detector analytical method was developed to determine the residue levels of flusilazole in grape and investigate the dissipation pattern and safety. The results showed that the mean recoveries were in the range of 86%-90%. Limits of detection and quantification were 0.008 and 0.02 mg/kg, respectively. The residue levels of flusilazole were best described by first-order rate kinetics and with half-lives ranging from 4.2 days (recommended dose) to 4.6 days (double the recommended dose). In conclusion, flusilazole at the recommended or even at double the recommended doses does not pose any apparent hazards to consumers.
ISSN:0277-2248
1029-0486
DOI:10.1080/02772248.2015.1092736