Oxidative stress involvement in manganese-induced alpha-synuclein oligomerization in organotypic brain slice cultures

Highlights ► Mn could cause oxidative damage to the cell membrane. ► Mn could enhance the expressions of alpha-synuclein mRNA and protein. ► Oxidative stress and Mn common promoted alpha-synuclein oligomerization. ► Both alpha-synuclein oligomers and oxidative stress caused nerve cell damage....

Full description

Saved in:
Bibliographic Details
Published in:Toxicology (Amsterdam) 2013-03, Vol.305, p.71-78
Main Authors: Xu, Bin, Wu, Sheng-Wen, Lu, Chun-Wei, Deng, Yu, Liu, Wei, Wei, Yan-Gang, Yang, Tian-Yao, Xu, Zhao-Fa
Format: Article
Language:English
Subjects:
alpha-Synuclein - metabolism
Alpha-synuclein oligomerization
Animals
Apoptosis - drug effects
Basal Ganglia - drug effects
Basal Ganglia - metabolism
Blotting, Western
Brain
Brain - pathology
Brain Chemistry - drug effects
Culture
Damage
Emergency
Glutathione - metabolism
Hydrogen Peroxide - metabolism
L-Lactate Dehydrogenase - metabolism
Manganese
Manganese - toxicity
Manganese Poisoning - metabolism
Manganese Poisoning - pathology
Membranes
Neurons - pathology
Neurotoxicity
Oligomerization
Organ Culture Techniques
Oxidative stress
Oxidative Stress - physiology
Pretreatment
Protein Carbonylation - drug effects
Proteins
Rats
Rats, Wistar
Reactive Oxygen Species - metabolism
Real-Time Polymerase Chain Reaction
RNA - biosynthesis
RNA - isolation & purification
Stresses
Sulfhydryl Compounds - metabolism
Superoxide Dismutase - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights ► Mn could cause oxidative damage to the cell membrane. ► Mn could enhance the expressions of alpha-synuclein mRNA and protein. ► Oxidative stress and Mn common promoted alpha-synuclein oligomerization. ► Both alpha-synuclein oligomers and oxidative stress caused nerve cell damage.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2013.01.006