Rapid prototyping of microfluidic chips for dead-volume-free MS coupling

A fast and straightforward method to prototype microfluidic chip systems for dead-volume-free hyphenation to electrospray-ionisation mass spectrometry is presented. The developed approach based on liquid-phase lithography provides an inexpensive and reliable access to microfluidic chips for MS coupl...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2015-11, Vol.407 (29), p.8735-8743
Main Authors: Dietze, Claudia, Scholl, Tobias, Ohla, Stefan, Appun, Johannes, Schneider, Christoph, Belder, Detlev
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Blood vessels
Capillaries
Characterization and Evaluation of Materials
chemical analysis
Chemistry
Chemistry and Materials Science
Chips
equipment design
equipment performance
Food Science
Joining
Lab-on-a-chip
Laboratories
Laboratory Medicine
Lithography
Mass spectrometry
Mathematical analysis
Microfluidics
Monitoring/Environmental Analysis
Polymers
Prototyping
Rapid prototyping
Research Paper
Scientific imaging
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Summary:A fast and straightforward method to prototype microfluidic chip systems for dead-volume-free hyphenation to electrospray-ionisation mass spectrometry is presented. The developed approach based on liquid-phase lithography provides an inexpensive and reliable access to microfluidic chips for MS coupling which can be manufactured in any laboratory with low technical demands. The rapid prototyping approach enables the seamless integration of capillaries serving as electrospray emitters with negligible dead volume. The high versatility of the presented prototyping method and the applicability of a variety of chip-based devices in different fields of lab-on-a-chip technology are established for analytical separations by means of chip-electrochromatography–MS and for continuous-flow synthesis using microreactor technology with MS detection.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-015-9027-1