Rational design of multifunctional magnetic mesoporous silica nanoparticle for tumor-targeted magnetic resonance imaging and precise therapy

Abstract In this paper, a multifunctional theranostic magnetic mesoporous silica nanoparticle (MMSN) with magnetic core was developed for magnetic-enhanced tumor-targeted MR imaging and precise therapy. The gatekeeper β-cyclodextrin (β-CD) was immobilized on the surface of mesoporous silica shell vi...

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Published in:Biomaterials 2016-01, Vol.76, p.87-101
Main Authors: Chen, Wei-Hai, Luo, Guo-Feng, Lei, Qi, Cao, Feng-Yi, Fan, Jin-Xuan, Qiu, Wen-Xiu, Jia, Hui-Zhen, Hong, Sheng, Fang, Fang, Zeng, Xuan, Zhuo, Ren-Xi, Zhang, Xian-Zheng
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Antibiotics, Antineoplastic - therapeutic use
Biomedical materials
Cancer
Cercopithecus aethiops
COS Cells
Dentistry
Doxorubicin - therapeutic use
Drugs
HeLa Cells
Humans
Imaging
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Mesoporous silica nanoparticle
Mice
Mice, Inbred BALB C
Microscopy, Electron, Transmission
Nanoparticles
Nanostructure
Neoplasms - drug therapy
Neoplasms - pathology
Precise therapy
Silicon Dioxide
Surgical implants
Theranostic
Theranostic Nanomedicine
Therapy
Tumor-targeted
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Summary:Abstract In this paper, a multifunctional theranostic magnetic mesoporous silica nanoparticle (MMSN) with magnetic core was developed for magnetic-enhanced tumor-targeted MR imaging and precise therapy. The gatekeeper β-cyclodextrin (β-CD) was immobilized on the surface of mesoporous silica shell via platinum(IV) prodrug linking for reduction-triggered intracellular drug release. Then Arg-Gly-Asp (RGD) peptide ligand was further introduced onto the gatekeeper β-CD via host–guest interaction for cancer targeting purpose. After active-targeting endocytosis by cancer cells, platinum(IV) prodrug in MMSNs would be restored to active platinum(II) drug in response to the innative reducing microenvironment in cancer cells, resulting in the detachment of β-CD gatekeeper and thus simultaneously triggering the in situ release of anticancer drug doxorubicin (DOX) entrapped in the MMSNs to kill cancer cells. It was found that with the aid of an external magnetic field, drug loaded MMSNs showed high contrast in MR imaging in vivo and exhibited magnetically enhanced accumulation in the cancer site, leading to significant inhibition of cancer growth with minimal side effects. This multifunctional MMSN will find great potential as a theranostic nanoplatform for cancer treatment.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2015.10.053