Multi-drug intoxication fatality involving atorvastatin: A case report

Highlights • Intoxication with antihypertensives and atorvastatin poses a high risk of fatality. • Atorvastatin-induced myotoxicity is dose-dependent and intensifies with verapamil. • Prescription of vasoactive agents and statins to alcoholics may be hazardous.

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Bibliographic Details
Published in:Forensic science international 2015-12, Vol.257, p.e26-e31
Main Authors: Cibickova, Lubica, Caran, Tomas, Dobias, Martin, Ondra, Peter, Vorisek, Viktor, Cibicek, Norbert
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Aged
Alcohol
Alcoholics
Anthraquinones - analysis
Anthraquinones - poisoning
Anti-Inflammatory Agents - analysis
Anti-Inflammatory Agents - poisoning
Antihypertensive
Antihypertensive Agents - analysis
Antihypertensive Agents - poisoning
Atorvastatin - analysis
Atorvastatin - poisoning
Blister packs
Blood pressure
Chromatography
Death
Drug dosages
Drug Overdose
Ethanol
Female
Forensic sciences
Forensic Toxicology
Gas chromatography
Gastrointestinal Contents - chemistry
Glucose
Hospitalization
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - analysis
Hydroxymethylglutaryl-CoA Reductase Inhibitors - poisoning
Hypolipidemic
Imidazoles - analysis
Imidazoles - poisoning
Indoles - analysis
Indoles - poisoning
Intensive care
Intoxication
Kinases
Laboratories
Mass spectrometry
Metabolites
Mortality
Pathology
Patients
Piperazines - analysis
Piperazines - poisoning
Rhabdomyolysis
Rhabdomyolysis - chemically induced
Rhabdomyolysis - pathology
Scientific imaging
Sensors
Serums
Suicide
Tablets
Urine
Vasodilator Agents - analysis
Vasodilator Agents - poisoning
Verapamil - analysis
Verapamil - poisoning
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Description
Summary:Highlights • Intoxication with antihypertensives and atorvastatin poses a high risk of fatality. • Atorvastatin-induced myotoxicity is dose-dependent and intensifies with verapamil. • Prescription of vasoactive agents and statins to alcoholics may be hazardous.
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2015.09.020