Simplified protocol of cardiac 18F-fluorodeoxyglucose positron emission tomography viability study in normoglycemic patients with known coronary artery disease

Abstract Purpose The purpose was to evaluate quality of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) myocardial scans and its correlation with background glucose (BG) after simplified 5% intravenous glucose load protocol. Methods An intravenous glucose load protocol was applied...

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Bibliographic Details
Published in:Clinical imaging 2015-07, Vol.39 (4), p.592-596
Main Authors: Kobylecka, Małgorzata, Płazińska, Maria Teresa, Mazurek, Tomasz, Bajera, Adam, Słowikowska, Anna, Fronczewska-Wieniawska, Katarzyna, Chojnowski, Marek, Mączewska, Joanna, Bąk, Marianna, Królicki, Leszek
Format: Article
Language:English
Subjects:
Aged
Body mass index
Body size (biology)
Cardiovascular disease
Coronary artery disease
Coronary Artery Disease - diagnostic imaging
Diabetes
FDG-PET/CT
Female
Fluorodeoxyglucose F18
Glucose
Glucose load protocol
Heart - diagnostic imaging
Humans
Insulin
Male
Metabolism
Middle Aged
Myocardial perfusion
Myocardial viability
Optimization
Patients
Positron emission
Positron-Emission Tomography - methods
Quality standards
Radiology
Software
Standardization
Studies
Tomography
Viability
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Summary:Abstract Purpose The purpose was to evaluate quality of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) myocardial scans and its correlation with background glucose (BG) after simplified 5% intravenous glucose load protocol. Methods An intravenous glucose load protocol was applied in 69 normoglycemic patients with confirmed coronary artery disease. The blood glucose level was measured every 15 min. Results Eighty-four percent of images were optimal, 8.7% suboptimal, and 7.3% uninterpretable. The quality of 18F-FDG-PET was BG independent and body mass index dependent ( P = .0007). Conclusions Simplified glucose load protocol is a safe and efficient method of preparation for FDG cardiac viability study in patients with normoglycemia.
ISSN:0899-7071
1873-4499
DOI:10.1016/j.clinimag.2015.02.009