Synthesis of multifunctional bovine serum albumin microcapsules by the sonochemical method for targeted drug delivery and controlled drug release

Novel multifunctional BSA microcapsules are prepared for hydrophobic drugs based on the sonochemical method. The microcapsules are smart carriers for targeted drug delivery and controlled drug release. [Display omitted] •FA-BSA@Fe3O4 MCs are prepared by the sonochemical method.•FA-BSA@Fe3O4 MCs are...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2015-12, Vol.136, p.470-478
Main Authors: Li, Zhanfeng, Xu, Fengzhi, Li, Quanshun, Liu, Songfeng, Wang, Hongyan, Möhwald, Helmuth, Cui, Xuejun
Format: Article
Language:English
Subjects:
Biomaterials
Capsules
Carriers, Drug
Drug Delivery Systems
Drugs
Folic acid
HeLa Cells
Humans
Magnetic properties
Microcapsule
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Multifunctional
Release
Serum Albumin, Bovine - chemistry
Sonochemical
Synthesis
Targeted
Uptakes
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Summary:Novel multifunctional BSA microcapsules are prepared for hydrophobic drugs based on the sonochemical method. The microcapsules are smart carriers for targeted drug delivery and controlled drug release. [Display omitted] •FA-BSA@Fe3O4 MCs are prepared by the sonochemical method.•FA-BSA@Fe3O4 MCs are non-toxic and have a suitable size range.•FA-BSA@Fe3O4 MCs are magnetic and molecular dual-targeted for specific delivery.•FA-BSA@Fe3O4 MCs are thermo- and redox-responsive for controlled drug release. Multifunctional folic acid conjugated BSA@Fe3O4 microcapsules (FA-BSA@Fe3O4 MCs) have been prepared successfully based on the sonochemical method. The as-synthesized FA-BSA@Fe3O4 MCs have a suitable size range for biomedical applications, and a high loading capacity for water-insoluble drugs. Furthermore, FA-BSA@Fe3O4 MCs show excellent magnetic properties. Cytotoxicity tests indicate that FA-BSA@Fe3O4 MCs are non-toxic. Cellular uptake and flow cytometric assay illustrate together that FA-BSA@Fe3O4 MCs can target tumor cells selectively through molecular targeted endocytosis. As carriers for water-insoluble drugs, FA-BSA@Fe3O4 MCs are also proved to possess superior redox- and thermo- dual responsiveness for controlled drug release.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2015.09.056