Acute exposure to Buenos Aires air particles (UAP-BA) induces local and systemic inflammatory response in middle-aged mice: A time course study

• Published in: Environmental pollution (1987) 2016-01, Vol.208 (Pt A), p.261-270
• Main Authors: Orona, Nadia S., Ferraro, Sebastián A., Astort, Francisco, Morales, Celina, Brites, Fernando, Boero, Laura, Tiscornia, Gisela, Maglione, Guillermo A., Saldiva, Paulo H.N., Yakisich, Sebastian, Tasat, Deborah R.
• Format: Article
• Language: English
• Subjects: Aging; Air Pollutants - analysis; Air Pollutants - toxicity; Air pollution; Animals; Argentina; Biomarkers - blood; Bronchoalveolar Lavage Fluid - immunology; Cardiorespiratory system; Cardiovascular Diseases - chemically induced; Cardiovascular Diseases - immunology; Coal Ash - analysis; Coal Ash - toxicity; Exposure; Fly ash; Heart - drug effects; Impact analysis; Inflammation; Inflammatory response; Inhalation Exposure - adverse effects; Inhalation Exposure - analysis; Interleukin-6 - blood; Interleukin-6 - immunology; Lung - drug effects; Lung - pathology; Male; Mice; Mice, Inbred BALB C; Myocardium - immunology; Myocardium - pathology; Oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - immunology; Particulate emissions; Particulate Matter - analysis; Particulate Matter - toxicity; Reduction; Urban air pollution
• ISSN: 0269-7491; 1873-6424
• DOI: 10.1016/j.envpol.2015.07.020

Exposure to air particulate matter (PM) is associated with increased cardiovascular morbimortality. However, PM doesn't affect equally to all people, being the old cohort the most susceptible and studied. We hypothesized that another specific life phase, the middle-aged subpopulation, may be negatively affected. Therefore, the aim of this study was to analyze in vivo the acute biological impact of two environmental particles, Urban Air Particles from Buenos Aires and Residual Oil Fly Ash, on the cardiorespiratory system of middle-aged mice, evaluating oxidative metabolism and inflammation. Both PM provoked a local and systemic inflammatory response, leading to a reduced alveolar area in the lung, an epicard inflammation in the heart, an increment of IL-6, and a reduction on PON 1 activity in serum of middle-aged animals. The positive correlation of local parameters with systemic markers of oxidative stress and inflammation could be responsible for associations of cardiovascular morbimortality in this subpopulation. •Buenos Aires Air Particles impact on the cardiorespiratory system of middle-aged animals.•Buenos Aires air particles induce lung and heart inflammation through time.•Buenos Aires air particles (UAP-BA) exposure provoked reduction on PON 1 activity.•Inflammation and oxidative stress generated by UAP-BA alter the cardiorespiratory system. Inflammation and oxidative stress generated by Buenos Aires Air Particles could be altering the cardiorespiratory system in middle-aged population.