Location, location, location (and density) of gap junctions in multi-compartment models

Interneuronal networks are important in mediating several rhythmic brain states. Their interconnections include dendritic gap junctions which can give rise to various network patterns depending on their location and density. We develop full and reduced (two-compartment) multi-compartment models of h...

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Bibliographic Details
Published in:Neurocomputing (Amsterdam) 2004-06, Vol.58, p.713-719
Main Authors: Saraga, Fernanda, Skinner, Frances K.
Format: Article
Language:English
Subjects:
Hippocampus
Interneurons
Neural networks
Oscillations
Phase-locking
Synchrony
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Summary:Interneuronal networks are important in mediating several rhythmic brain states. Their interconnections include dendritic gap junctions which can give rise to various network patterns depending on their location and density. We develop full and reduced (two-compartment) multi-compartment models of hippocampal basket cells and examine two-cell networks of them. The location and density of the gap junctions determine if and when synchronous and phase-locked patterns arise. Comparison of the full and reduced network models allows us to obtain biological quantification of gap junction conductance values in the reduced models.
ISSN:0925-2312
1872-8286
DOI:10.1016/j.neucom.2004.01.118