Astrocytes in physiological aging and Alzheimer’s disease

Highlights • Astrocytes are fundamental for homoeostasis, defence and regeneration of the CNS. • In Alzheimer’s disease (AD) astrocytes undergo degeneration and atrophy. • Atrophy of astrocytes alters homeostatic reserve of the brain. • Astrocytes can be regulated through environmental stimulation a...

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Bibliographic Details
Published in:Neuroscience 2016-05, Vol.323, p.170-182
Main Authors: Rodríguez-Arellano, J.J, Parpura, V, Zorec, R, Verkhratsky, A
Format: Article
Language:English
Subjects:
aging
Aging - drug effects
Aging - pathology
Aging - physiology
Alzheimer Disease - pathology
Alzheimer Disease - physiopathology
Alzheimer Disease - therapy
Alzheimer’s disease
Animals
astrocyte
Astrocytes - drug effects
Astrocytes - pathology
Astrocytes - physiology
Brain - drug effects
Brain - pathology
Brain - physiology
Brain - physiopathology
Humans
neurodegeneration
neuroglia
Neurology
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Summary:Highlights • Astrocytes are fundamental for homoeostasis, defence and regeneration of the CNS. • In Alzheimer’s disease (AD) astrocytes undergo degeneration and atrophy. • Atrophy of astrocytes alters homeostatic reserve of the brain. • Astrocytes can be regulated through environmental stimulation and/or medication. • Astrocytes can be targeted for prevention and cure of neurodegenerative disorders.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.01.007