Prevalence of vitamin D deficiency in HIV-positive, antiretroviral treatment-naïve patients in a single centre study

• Published in: International journal of STD & AIDS 2014-06, Vol.25 (7), p.488-492
• Main Authors: Gedela, Keerti, Edwards, Simon G, Benn, Paul, Grant, Alison D
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; AIDS/HIV; CD4 Lymphocyte Count; Female; HIV Infections - complications; HIV Infections - diagnosis; HIV Infections - epidemiology; HIV-1; Humans; London - epidemiology; Male; Middle Aged; Prevalence; Retrospective Studies; Risk Factors; Viral Load; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - epidemiology; Young Adult
• ISSN: 0956-4624; 1758-1052
• DOI: 10.1177/0956462413515194

The objective of this study was to describe the prevalence of vitamin D deficiency among antiretroviral treatment-naïve, HIV-positive individuals. We reviewed records of consecutive antiretroviral treatment-naïve patients, registering for care for the first time at a London clinic from 01 January 2008 to 31 December 2009. During this period, serum 25-hydroxycholecalciferol was measured routinely for all new patients. 25-hydroxycholecalciferol deficiency and severe deficiency were defined as ≤50 and ≤25 nmol/L, respectively. Among 253 patients (82% men, median age 36 years, 64% white ethnicity), 148 (58.5%) were 25-hydroxycholecalciferol-deficient, including 32 (12.6%) who were severely deficient. In all, 73.5% (61/83) patients of non-white ethnicity were 25-hydroxycholecalciferol-deficient compared with 50.7% (76/150) of those reporting white ethnicity (p