Actin’g against the Ball and Chain

Spinocerebellar ataxia type 13 is a rare autosomal-dominant neurodegenerative disease induced by mutations in the voltage-dependent Kv3.3 potassium channel. Recently in Cell, Zhang et al. (2016) provide new insights into how Arp2/3-dependent actin polymerization modulates both Kv3.3 activity and its...

Full description

Saved in:
Bibliographic Details
Published in:Developmental cell 2016-04, Vol.37 (1), p.11-12
Main Authors: Abella, Jasmine V.G., Way, Michael
Format: Article
Language:English
Subjects:
Actins - genetics
Humans
Mutation
Shaw Potassium Channels
Spinocerebellar Degenerations
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Spinocerebellar ataxia type 13 is a rare autosomal-dominant neurodegenerative disease induced by mutations in the voltage-dependent Kv3.3 potassium channel. Recently in Cell, Zhang et al. (2016) provide new insights into how Arp2/3-dependent actin polymerization modulates both Kv3.3 activity and its ability to stimulate actin polymerization via Hax-1. Spinocerebellar ataxia type 13 is a rare autosomal-dominant neurodegenerative disease induced by mutations in the voltage-dependent Kv3.3 potassium channel. Recently in Cell, Zhang et al. (2016) provide new insights into how Arp2/3-dependent actin polymerization modulates both Kv3.3 activity and its ability to stimulate actin polymerization via Hax-1.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2016.03.014