Prognostic factors in sporadic colon cancer with high-level microsatellite instability

Background The microsatellite instability–high (MSI-H) phenotype of colon cancer has a good prognosis and limited response to chemotherapy. We aimed to investigate prognostic factors and oncologic outcomes in patients with MSI-H sporadic colon cancer. Methods A total of 329 patients with MSI-H spora...

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Published in:Surgery 2016-05, Vol.159 (5), p.1372-1381
Main Authors: Oh, Bo Young, MD, PhD, Huh, Jung Wook, MD, PhD, Park, Yoon Ah, MD, Cho, Yong Beom, MD, PhD, Yun, Seong Hyeon, MD, PhD, Kim, Hee Cheol, MD, PhD, Lee, Woo Yong, MD, PhD, Chun, Ho-Kyung, MD, PhD
Format: Article
Language:English
Subjects:
Adenocarcinoma - drug therapy
Adenocarcinoma - genetics
Adenocarcinoma - mortality
Adenocarcinoma - surgery
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Chemotherapy, Adjuvant
Colonic Neoplasms - drug therapy
Colonic Neoplasms - genetics
Colonic Neoplasms - mortality
Colonic Neoplasms - surgery
Female
Follow-Up Studies
Humans
Male
Microsatellite Instability
Middle Aged
Neoplasm Staging
Prognosis
Retrospective Studies
Surgery
Survival Analysis
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Summary:Background The microsatellite instability–high (MSI-H) phenotype of colon cancer has a good prognosis and limited response to chemotherapy. We aimed to investigate prognostic factors and oncologic outcomes in patients with MSI-H sporadic colon cancer. Methods A total of 329 patients with MSI-H sporadic colon cancer who underwent radical surgery from January 2004 to December 2012 at a single institution were included. We analyzed prognostic factors and oncologic outcomes according to chemotherapy in these patients compared with patients with MSI-low/microsatellite stable colon cancer. Results Among the 329 patients, 174 were male and 155 were female. The median age was 59 years. The population consisted of 220 patients with stage II, 97 with stage III, and 12 with stage IV disease. Old age and advanced stage were independent poor prognostic factors of overall survival (OS; P  = .014 and P  = .040, respectively) and advanced stage and presence of perineural invasion were independent poor prognostic factors of disease-free survival (DFS; P  = .004 and P  = .001, respectively). In addition, a greater number of poor prognostic factors were associated with worse survival ( P  
ISSN:0039-6060
1532-7361
DOI:10.1016/j.surg.2015.11.028